TREATMENT OF MILD HYPERTENSION

轻度高血压的治疗

• 批准号: 3346295
• 负责人: Thomas J. Coates
• 金额: $ 10.2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1989-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3346295
• 关键词: angers; antihypertensive agents; anxiety; atenolol; behavioral medicine; beta antiadrenergic agent; cardiovascular disorder chemotherapy; cardiovascular disorder diagnosis; cardiovascular disorder prevention; depression; drug adverse effect; exercise; human middle age (35-64); human subject; human therapy evaluation; hypertension; memory; perception; placebos; propranolol; psychomotor reaction time; saluresis; sex behavior; type A /type B personality; young adult human (21-34)

The goals of this competing continuation are (1) to complete the one-year follow-up of the study of the effects on blood pressure, cognition, and quality of life (affect, anxiety, sexual function and interest) of a lipophilic beta blocker compared to a non- pharmacological intervention (the Current Study) and (2) to complete a study of the effects on cognition, and quality of life of a lipophobic beta blocker in comparison to a lipophilic beta blocker and placebo (the New Study). The current study is comparing propranolol (vs placebo) and a non-pharmacological intervention (vs no intervention) in a 2 X 2 design. Assessments at baseline and 3 and 12 months include blood pressure (clinic and ambulatory), cognition, depression, anxiety, sexual interest and function, Type A, anger, and other side effects. A total of 300 subjects will be randomized by January 1988, with the one-year follow-up completed in January 1989. 3-month data indicate main effects of propranolol on blood pressure, side effects, and some cognitive functions. The non-pharmacologic intervention has shown a main effect on urinary sodium and trends for exercise. There is a significant interaction effect of drug and non- pharmacologic intervention on blood pressure. Because the liposolubility of beta blockers is a key determinant in the distribution of the drug throughout the body, the Follow-up Study will compare, in a randomized double-blind protocol, a lipophilic beta blocker (propranolol) with a lipophobic beta blocker (atenolol) and a placebo over a 3 month period. A total of 50 subjects will be randomized to each arm, with assessments at baseline, 2 weeks, and 3 months. Recruitment and randomization will begin in June 1988 (pending approval of this application) and be completed in June 1989.

这一竞争延续的目标是(1)完成 对血压影响研究的一年随访， 认知和生活质量(情感、焦虑、性功能和 兴趣)与非亲脂性β受体阻滞剂相比 药物干预(本研究)和(2) 完成对认知和生活质量影响的研究 疏脂型β受体阻滞剂与亲脂型β受体阻滞剂的比较 阻滞剂和安慰剂(新研究)。目前的研究是 普萘洛尔(与安慰剂)和非药理学药物的比较 干预(与不干预)采用2×2设计。评估时间： 基线、3个月和12个月包括血压(临床和 动态的)、认知、抑郁、焦虑、性兴趣和 功能、A型、愤怒和其他副作用。总共300个 受试者将在1988年1月之前随机进行，为期一年 跟进工作已於一九八九年一月完成。3个月数据显示主要 心得安对血压、副作用等的影响 认知功能。非药物干预有 显示了对尿钠和运动趋势的主要影响。 药物与非药物之间存在显著的交互作用。 对血压的药物干预。 因为β-受体阻滞剂的脂溶性是 药物在体内的分布情况，随访情况 这项研究将在随机双盲方案中比较 亲脂性β受体阻滞剂(心得安)与疏脂性β受体阻滞剂 (阿替洛尔)和安慰剂，为期3个月。总共50个 受试者将被随机分配到每一组，评估时间为 基线、2周和3个月。招募和随机化 将于1988年6月开始(等待本申请的批准)和 将于1989年6月完工。

项目成果

Propranolol and response bias: an extension of findings reported by Corwin et al.

普萘洛尔和反应偏差：Corwin 等人报告的研究结果的延伸。

• DOI: 10.1016/0006-3223(91)90021-d
• 发表时间: 1991
• 期刊: Biological psychiatry
• 影响因子: 10.6
• 作者: Callaway,E;Halliday,R;Perez-Stable,EJ;Coates,TJ;Hauck,WW
• 通讯作者: Hauck,WW

Differential effects of exercise training on skeletal muscle SERCA gene expression.

运动训练对骨骼肌 SERCA 基因表达的不同影响。

• DOI: 10.1097/00005768-200301000-00005
• 发表时间: 2003
• 期刊: Medicine and science in sports and exercise
• 影响因子: 4.1
• 作者: Kubo,Hajime;Libonati,JosephR;Kendrick,ZebulonV;Paolone,Albert;Gaughan,JohmP;Houser,StevenR
• 通讯作者: Houser,StevenR

The effects of mild diastolic hypertension on the results of tests of cognitive function in adults 22 to 59 years of age.

轻度舒张期高血压对 22 至 59 岁成人认知功能测试结果的影响。

• DOI: 10.1007/bf02599096
• 发表时间: 1992
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Pérez-Stable,EJ;Coates,TJ;Halliday,R;Gardiner,PS;Hauck,WW
• 通讯作者: Hauck,WW