Cross-Metathesis Based Routes to Heteroaromatic Systems

化学是一门充满活力的学科，是许多不同科学进步的中心。有机化学与碳的所有不同形式的反应性有关，可以被视为发生在生物体内的化学。化学家们一直在寻找设计和制造分子的新方法(合成化学就是分子结构)，这项提议描述了一种使用新型催化剂制造有价值的分子的简短而强大的新方法。该提案的核心分子是杂环芳香化合物，它们具有特殊的性质，是许多已知药物的基础。为了强调这些杂环的重要性，提案中提到的6种类型或芳烃出现在2008年零售额最高的15种品牌药物中的7种。本文提出的新型化学方法将为利用催化作用控制官能团的掺入和取代模式来制备杂芳烃提供一种新的、高效和有效的方法：这将对学术界和工业界都有很大的好处。我们还计划筛选出具有广泛生物活性的化合物。有鉴于此，我们迫切需要有新的、有效的和强大的方法来制造新的杂环芳香化合物，以便我们能够研究和使用它们。此外，新催化剂和催化系统的开发和应用也很重要，因为它使化学反应运行得更快、更清洁、废物更少：这显然对工业和环境都是一件好事。

Chemistry is a dynamic subject that is at the centre of many different scientific advances. Organic chemistry is concerned with the reactivity of carbon in all its different forms and can be viewed as the chemistry taking place within living things. Chemists are constantly looking for new ways of designing and building molecules (synthetic chemistry is molecular architecture) and this proposal describes a short and powerful new way of making valuable molecules using a new type of catalyst. The molecules at the heart of the proposal are heterocyclic aromatic compounds which have special properties and are the building blocks of many known pharmaceutical agents. To underscore the importance of these heterocycles, the 6 types or arene mentioned in the proposal are present in 7 of the top 15 brand name drugs by retail sales in 2008. The novel chemistry proposed here will provide a new, efficient and powerful way of making heteroarenes using catalysis to control functional group incorporation and substitution pattern: this will be of great benefit to both academia and industry. Plans have also been made to screen the compounds that we make for a wide range of biological activity.Given all of the above, it is imperative that we have novel, efficient and powerful methods for making new heterocyclic aromatic compounds so that we can study and use them. In addition, the development and application of new catalysts and catalytic systems is also important because it makes chemical reactions run faster, cleaner and with less waste: this is clearly a good thing for industry and also for the environment.