A study into the mechanism and utility of single electron reduction in organic synthesis

有机合成中单电子还原的机理及应用研究

• 批准号: EP/E017738/1
• 负责人: Timothy Donohoe
• 金额: $ 44.3万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE017738%2F1
• 关键词: study; into; mechanism; utility; single

This proposal seeks to develop a new and more efficient way to prepare complex organic molecules. Our efforts will focus on the addition of electrons to a variety of organic compounds because this process can transform them into especially useful new derivatives.We aim to use an electron shuttle to transfer electrons from the surface of a metal to the organic compound in question; an understanding of the way that this works is of paramount importance if we are to optimise and harness it. By using a combination of electochemistry and preparative chemistry, we aim to delve deep into the mechanism of a complex process and emerge with a range of new reducing conditions.This will result in the development of selective new reduction reactions, which is important to chemical industry as well as academia because it enables valuable organic compounds to be prepared quickly and efficiently with minimisation of cost and waste produced.

该提案旨在开发一种新的更有效的方法来制备复杂的有机分子。我们的工作将集中在电子添加到各种有机化合物，因为这个过程可以将它们转化为特别有用的新衍生物。我们的目标是使用电子穿梭将电子从金属表面转移到所讨论的有机化合物;如果我们要优化和利用它，了解它的工作方式是至关重要的。通过使用电化学和在制备化学方面，我们的目标是深入研究复杂过程的机理，并提出一系列新的还原条件。这将导致选择性的新还原反应的发展，这对化学工业和学术界都很重要，因为它使有价值的有机化合物能够快速有效地制备，同时最大限度地减少成本和产生的废物。

项目成果

Electrochemistry in tetrahydrofuran and at low temperature: protocol, procedures and methods

四氢呋喃和低温下的电化学：方案、程序和方法

• DOI: 10.1002/poc.1574
• 发表时间: 2009
• 期刊: Journal of Physical Organic Chemistry
• 影响因子: 1.8
• 作者: Baron R