New techniques for the formation of enantiopure heterocycles

形成对映体纯杂环的新技术

• 批准号: EP/D033365/1
• 负责人: Timothy Donohoe
• 金额: $ 18.06万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD033365%2F1
• 关键词: New; techniques; formation; enantiopure; heterocycles

Chemistry is a dynamic subject that is at the centre of many different scientific advances. Organic chemistry is concerned with the reactivity of carbon in all its different forms and can be viewed as the chemistry taking place within living things. Chemists are constantly looking for new ways of designing and building molecules (synthetic chemistry is molecular architecture) and this proposal describes a short and powerful new way of making valuable molecules using a new type of approach. The molecules at the heart of this proposal are cyclic compounds (called heterocyclic compounds), which are widespread materials with a variety of useful properties. They are present in many natural products and are central to the drug discovery process: clearly, there is significant interest in new ways of preparing them. Industry is constantly searching for new approaches to heterocyclic compounds and especially efficient new routes. New and smarter ways of making these important compounds is a useful goal because it enables reactions to be run faster, cleaner and with less waste- this is a good thing for industry and for the environment.

化学是一门充满活力的学科，是许多不同科学进步的中心。有机化学关注的是碳在所有不同形式中的反应性，可以被视为生物体内发生的化学。化学家们一直在寻找设计和构建分子的新方法（合成化学是分子结构），这项提议描述了一种使用新型方法制造有价值分子的简短而强大的新方法。该提议的核心分子是环状化合物（称为杂环化合物），它们是具有各种有用性质的广泛材料。它们存在于许多天然产物中，是药物发现过程的核心：显然，人们对制备它们的新方法非常感兴趣。工业界一直在寻找制备杂环化合物的新方法，特别是有效的新路线。制造这些重要化合物的新的和更智能的方法是一个有用的目标，因为它使反应运行得更快，更清洁，废物更少-这对工业和环境都是好事。