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Catalytic chemistry for methanol oxidation: a study into mechanism and utility

甲醇氧化催化化学：机理和实用性研究

基本信息

批准号：
EP/L023121/1
负责人：
Timothy Donohoe
金额：
$ 124.9万
依托单位：
University of Oxford
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2014
资助国家：
英国
起止时间：
2014 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FL023121%2F1
关键词：
Catalytic chemistry methanol oxidation study

项目摘要

Chemistry is a dynamic subject that is at the centre of many different scientific advances. Organic chemistry is concerned with the reactivity of carbon in all its different forms and can be viewed as the chemistry taking place within living things. Chemists are constantly looking for new ways of designing and building molecules (synthetic chemistry is molecular architecture) and this proposal describes a short and powerful new way of making valuable molecules using a new type of catalyst. The molecules at the heart of the proposal are compounds containing a carbon-oxygen double bond (a carbonyl group) which have special properties and are the building blocks of many known pharmaceutical agents. The novel chemistry proposed here will provide a new, efficient and powerful way of making carbonyl compounds using catalysis to control all aspects of the structures of the products formed: this will be of great benefit to both academia and industry who will be able to make interesting molecules (some that were otherwise inaccessible) in new ways. Plans have also been made to screen the compounds that we make for a wide range of biological activity.Given all of the above, it is imperative that we have novel, efficient and powerful methods for making new carbonyl containing compounds so that we can study and use them. In addition, the development and application of new catalysts and catalytic systems is also important because catalysis makes chemical reactions run faster, and become cleaner with less waste: this is clearly a good thing for industry and also for the environment. The Fellowship aspect of this proposal is designed to allow the principal investigator the time to study and develop a new research direction. Plans have been made to interact and collaborate with other academics who can provide specialist knowlege and also with two project partners (one a multi-national pharmaceutical company and the other a leading academic in the United States of America) so that industrial problems and mechanistic details can be identified and addressed at all stages of the project. Three post-doctoral assistants will be employed to carry out the exprimental work, and the project will provide a thorough and comprehensive training in science and the attendant areas of communication/ presentation and creativity. This will equip them very well for the job market afterwards.

化学是一门充满活力的学科，是许多不同科学进步的中心。有机化学关注的是碳在所有不同形式中的反应性，可以被视为生物体内发生的化学。化学家们一直在寻找设计和构建分子的新方法（合成化学是分子结构），这项提议描述了一种使用新型催化剂制造有价值分子的简短而强大的新方法。该提案的核心分子是含有碳-氧双键（羰基）的化合物，这些化合物具有特殊性质，是许多已知药物的构建单元。这里提出的新化学将提供一种新的，有效的和强大的方法来制造羰基化合物，使用催化剂来控制所形成的产物结构的各个方面：这将对学术界和工业界都有很大的好处，他们将能够以新的方式制造有趣的分子（一些是无法获得的）。我们还计划筛选具有广泛生物活性的化合物。鉴于上述所有情况，我们必须有新的，有效的和强大的方法来制备新的含羰基化合物，以便我们可以研究和使用它们。此外，新催化剂和催化系统的开发和应用也很重要，因为催化作用使化学反应更快，更清洁，废物更少：这对工业和环境都是一件好事。本提案的奖学金方面旨在让主要研究者有时间研究和开发新的研究方向。已制定计划，与能够提供专业知识的其他学术界和两个项目伙伴（一个是跨国制药公司，另一个是美利坚合众国的主要学术界）进行互动和合作，以便能够在项目的所有阶段查明和解决工业问题和机械细节。三名博士后助理将被雇用来进行实验工作，该项目将提供科学和通信/演示和创造力的相关领域的全面和全面的培训。这将使他们在以后的就业市场上做好充分的准备。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Synthesis of Cyclopropanes via Hydrogen-Borrowing Catalysis.

DOI：
10.1021/acs.orglett.3c01768
发表时间：
2023-07-21
期刊：
ORGANIC LETTERS
影响因子：
5.2
作者：
Crompton, Jessica L.;Frost, James R.;Rowe, Sam M.;Christensen, Kirsten E.;Donohoe, Timothy J.
通讯作者：
Donohoe, Timothy J.

Stereoselective synthesis of alicyclic ketones: A hydrogen borrowing approach