Exploiting the interface between aromaticity and non-aromaticity

化学是一门充满活力的学科，是许多不同科学进步的中心。有机化学关注的是碳在所有不同形式中的反应性，可以被视为生物体内发生的化学反应。化学家们一直在寻找设计和构建分子的新方法（合成化学本质上是分子结构），该提案描述了一种使用新的催化系统制造有价值分子的短而强大的新方法，该催化系统与甲醇结合作为（可再生资源）溶剂。该提案的核心分子是芳香环衍生物，它们存在于学术界和商业界的许多不同化合物中。催化的思想也是这项工作的核心;催化使用少量的关键促进剂（催化剂）使反应以没有它们就不可能的方式进行。本文提出的新化学方法将提供一种新的、有效的和强有力的方法，利用催化作用来控制所形成的产物结构的各个方面，从而制备环状和芳香族化合物：这对学术界和工业界都有很大的好处，他们将能够以新的方式制造有趣的分子。我们已经聘请了一位来自制药行业的项目合作伙伴，以便该项目能够迅速发展到对行业有直接利益和价值的领域。鉴于上述所有情况，我们必须拥有新颖、高效和强大的方法来制造新化合物，以便我们能够研究和使用它们。此外，新催化系统的开发和应用也很重要，因为催化使化学反应运行得更快，更清洁，废物更少：这显然对工业和环境都是一件好事。这一提议的真实的优势是尖端科学的发展及其应用，以解决与世界各地化学科学家相关的问题。

Chemistry is a dynamic subject that is at the centre of many different scientific advances. Organic chemistry is concerned with the reactivity of carbon in all of its different forms and can be viewed as the chemistry taking place within living things. Chemists are constantly looking for new ways of designing and building molecules (synthetic chemistry is essentially molecular architecture) and this proposal describes a short and powerful new way of making valuable molecules using a new catalytic system that works in combination with methanol as a (renewable resource) solvent. The molecules at the heart of the proposal are aromatic ring derivatives which are found in many different compounds of value in both the academic and commercial world. The idea of catalysis also lies at the heart of this work; and catalysis uses small amounts of key promoters (catalysts) to make reactions run in ways that are not possible without them. Catalysts are also added to a reaction in small quantities which has beneficial consequences for the efficiency of the chemical processes involved.The novel chemistry proposed herein will provide a new, efficient and powerful way of making cyclic and aromatic compounds using catalysis to control all aspects of the structures of the products formed: this will be of great benefit to both academia and industry who will be able to make interesting molecules in new ways. We have engaged a project partner from the pharmaceutical industry so that the project will develop rapidly into areas that are of direct interest and value to industry.Given all of the above, it is imperative that we have novel, efficient and powerful methods for making new compounds so that we can study and use them. In addition, the development and application of new catalytic systems is also important because catalysis makes chemical reactions run faster and cleaner with less waste: this is clearly a good thing for industry and also for the environment. The real advantage of this proposal is the development of cutting edge science and its application to solve problems that are relevant to chemical scientists around the world.