Exploiting the interface between aromaticity and non-aromaticity

化学是一门充满活力的学科，是许多不同科学进步的中心。有机化学研究各种不同形式的碳的反应性，可以看作是发生在生物体内的化学反应。化学家们一直在寻找设计和构建分子的新方法（合成化学本质上是分子结构），而这项提议描述了一种简短而强大的新方法，利用一种新的催化系统，与甲醇作为一种（可再生资源）溶剂相结合，制造有价值的分子。该提议的核心分子是芳香环衍生物，它们存在于许多不同的化合物中，在学术和商业领域都有价值。催化作用的概念也是这项工作的核心；催化作用使用少量的关键启动子（催化剂）使反应以没有它们就不可能进行的方式进行。少量的催化剂也被加入到反应中，这对所涉及的化学过程的效率有有益的影响。本文提出的新化学将提供一种新的、有效的、强大的方法来制造环状和芳香化合物，利用催化来控制所形成产物结构的各个方面：这将对学术界和工业界都有很大的好处，他们将能够以新的方式制造有趣的分子。我们已经聘请了一个来自制药行业的项目合作伙伴，以便该项目将迅速发展到对行业有直接兴趣和价值的领域。鉴于以上所述，我们必须有新颖、有效和强大的方法来制造新化合物，以便我们能够研究和使用它们。此外，新催化系统的开发和应用也很重要，因为催化使化学反应进行得更快、更清洁、浪费更少：这显然对工业和环境都是一件好事。这一建议的真正优势在于尖端科学的发展及其应用，以解决与世界各地化学科学家相关的问题。

Chemistry is a dynamic subject that is at the centre of many different scientific advances. Organic chemistry is concerned with the reactivity of carbon in all of its different forms and can be viewed as the chemistry taking place within living things. Chemists are constantly looking for new ways of designing and building molecules (synthetic chemistry is essentially molecular architecture) and this proposal describes a short and powerful new way of making valuable molecules using a new catalytic system that works in combination with methanol as a (renewable resource) solvent. The molecules at the heart of the proposal are aromatic ring derivatives which are found in many different compounds of value in both the academic and commercial world. The idea of catalysis also lies at the heart of this work; and catalysis uses small amounts of key promoters (catalysts) to make reactions run in ways that are not possible without them. Catalysts are also added to a reaction in small quantities which has beneficial consequences for the efficiency of the chemical processes involved.The novel chemistry proposed herein will provide a new, efficient and powerful way of making cyclic and aromatic compounds using catalysis to control all aspects of the structures of the products formed: this will be of great benefit to both academia and industry who will be able to make interesting molecules in new ways. We have engaged a project partner from the pharmaceutical industry so that the project will develop rapidly into areas that are of direct interest and value to industry.Given all of the above, it is imperative that we have novel, efficient and powerful methods for making new compounds so that we can study and use them. In addition, the development and application of new catalytic systems is also important because catalysis makes chemical reactions run faster and cleaner with less waste: this is clearly a good thing for industry and also for the environment. The real advantage of this proposal is the development of cutting edge science and its application to solve problems that are relevant to chemical scientists around the world.