Transition Metal Catalysed Oxidation of Olefins: Application to the Synthesis of Heterocycles via Arrays

有机化学是研究碳的化学的学科。通过碳与氮和氧生成的化合物，它构成了所有生物的基础，了解碳基化合物相互作用的方式对于我们理解和控制生物过程至关重要。不--这一点比制药领域更重要，制药领域为人类的健康和福祉做出了重大贡献。药物发现是由有机化学家推动的，他们制造新的有机化合物来探索它们的性质及其与生物学的相互作用。有机化合物还有许多其他用途，如用作农用化学品、聚合物、人造酶、平板显示器、太阳能电池、光学开关和塑料电子产品的关键成分。因此，化学工业不断需要新的有机结构和制造有机化合物的新工具。在这种背景下，开发新的反应和新的方法来制造大量潜在的候选药物对于将有机合成和药物研究发展成为安全、高效和环境友好的企业至关重要。这里描述的新化学以有效和大量制造芳香化合物的方法为中心。芳香化合物是一类非常普遍、有用和广泛的化合物，是上述有机化学所有用途的核心。我们的目标是探索和优化一种控制芳香化合物形成的新程序，并将其转变为一个能够快速生成大量化合物(集合或库)的过程。上述所有杰出的科学描述都可以在培训一名博士后研究人员的背景下进行。这是一个严谨的过程，既涉及学术界和产业界，也涉及理论和实践。最终结果是一位训练有素、极具受雇能力的研究人员，他对化学领域的最新发展以及化学工业面临的独特挑战具有独特的视角。

Organic chemistry is the study of the chemistry of carbon. Through the compounds that carbon makes with nitrogen and oxygen, it forms the basis of all living things and understanding the way in which carbon based compounds interact with each other is of paramount importance if we are to understand and control biological processes. No-where is this more important than in the field of pharmaceuticals, which has made a substantial contribution to the health and well-being of mankind. Drug discovery is driven by organic chemists, who make novel organic compounds to explore their properties and interaction with biology. There are many other uses of organic compounds such as as key components of agrochemicals, polymers, artificial enzymes, flat panel displays, solar cells, optical switches, and plastic electronics. Consequently, chemical industry has a constant need for new organic structures and for new tools for making organic compounds. Within this context, the development of new reactions and new ways of making large numbers of potential drug candidates is vital to develop organic synthesis and pharmaceutical research into a safe, efficient and environmentally friendly enterprise. The new chemistry described here centres around ways of making aromatic compounds efficiently and in large numbers. Aromatic compounds are a very general, useful and broad class of compound and are central to all of the uses of organic chemistry mentioned above.We aim to explore and optimise a new procedure for controlling the formation of aromatic compounds, and will turn it into a process that is able to make significant numbers of compounds (collections or libraries) rapidly.All of the outstanding science descibed above can be conducted in the context of training one postdoctoral researcher. This is a rigorous process that involves both academia and industry, and both theory and practice. The end result is a highly trained, and eminently employable, researcher who has a unique perspective on the latest developments in chemistry together with the unique challenges faced by chemical industry.