MUSCLE RECEPTORS

肌肉受体

• 批准号: 3393685
• 负责人: CARLTON C HUNT
• 金额: $ 10.96万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-01-01 至 1988-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3393685
• 关键词: afferent nerve; axon; electron microscopy; evoked potentials; innervation; mechanoreceptors; membrane permeability; membrane potentials; microscopy; muscle contraction; muscle tension; myofibrils; neural information processing; neural initiation; neuromuscular junction; neuromuscular transmission; sarcomeres; stretch receptors

Mechanisms of sensory transduction and its modification by motor control will be studied in mammalian muscle spindles, both in situ and in isolated preparations. The membrane properties and contractile activation of intrafusal muscle fibers as well as their passive mechanical properties will be investigated using intracellular recording and stimulation and microscopic measurement of sarcomere length changes. The roles of the 2 types of nuclear bag fiber will be tested by activation of these fibers individually while observing the effect on the primary ending response to stretch. Possible stretch excitation in bag fibers will be studied. The conductance change in the sensory terminals in response to stretch will also be investigated as will the characteristics of impulse initiation in the primary ending.

感觉传导机制及其运动控制的调节 将在哺乳动物肌梭中进行研究，包括原位和分离的 准备工作 膜的性质和收缩激活 梭内肌纤维及其被动力学特性 将使用细胞内记录和刺激进行研究， 肌节长度变化的显微镜测量。 2的作用 核袋纤维的类型将通过这些纤维的活化来测试 同时观察对主要结束反应的影响， 伸展。 将研究袋纤维中可能的拉伸激发。 的 感觉末梢对牵拉的反应性的电导变化， 也将研究脉冲起爆的特点， 主要结局。