MUSCLE RECEPTORS

肌肉受体

• 批准号: 3393689
• 负责人: CARLTON C HUNT
• 金额: $ 14.42万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-01-01 至 1993-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3393689
• 关键词: afferent nerve; axon; biological signal transduction; cats; central nervous system disorders; electron microscopy; evoked potentials; innervation; mechanical stress; mechanoreceptors; membrane permeability; membrane potentials; microscopy; muscle contraction; muscle tension; myelination; myofibrils; neural conduction; neural information processing; neural initiation; neuromuscular junction; neuromuscular transmission; stress; stretch receptors

This research aims to increase our understanding of sensory transduction in somatic mechanoreceptors. Such receptors subserve a wide variety of sensory systems which convert mechanical forces to neural signals which are transmitted to the central nervous system. Very little information is available on the fundamental steps of the transduction process. We propose a study on the primary ending of the isolated mammalian muscle spindle which is an especially favorable preparation for a direct approach on the problem because of: the ability to study it in isolation, the relatively large size of the myelinated branches and their terminals, the accessibility of structures in our isolated decapsulated preparation and the ability to visualize its structure microscopically. Using newly developed techniques of imaging and patch clamping, we will investigate: 1) the conductance changes which occur in the nerve terminals in response to mechanical stress and the characteristics of stretch-activated channels. 2) the spread of potentials produced by the conductance changes along the myelinated branches of the ending and the site of impulse initiation, and 3) a quantitative study of the structure of the primary ending both its myelinated branches and unmyelinated terminals, which will allow us to derive an electrical model of the ending. This is essential for the interpretation of an understanding of the overall transduction process in the ending. Knowledge of the basic mechanisms of transduction may be very important for the understanding of many disorders affecting sensory systems.

这项研究旨在增加我们对感官的理解 躯体机械感受器中的转导。这样的受体可以替代 各种各样的感官系统将机械力转化为 传递到中枢神经的神经信号 系统。关于基本面的信息很少。 转导过程的步骤。我们建议进行一项关于 分离的哺乳动物肌梭的初级末端 特别有利的准备是直接接近 问题的原因是：能够孤立地研究它， 相对较大的有髓分支及其 终点站，我们孤立的结构的可达性 解囊制剂及其结构的可视化能力 显微镜下看。使用新开发的成像技术和 膜片钳，我们将研究：1)电导变化 它们发生在神经末梢对机械应力的反应 以及拉伸激活通道的特性。2) 由电导变化所产生的电势沿 末梢和冲动部位的有髓分支 3)结构的定量研究。 其有髓分支和无髓分支均为原发末梢 端子，这将使我们能够推导出一个电气模型 结束了。这对于解释 在结尾理解整个转导过程。 对转导的基本机制的了解可能非常重要 对许多影响感官的障碍的理解很重要 系统。