BIOMECHANISMS OF TOOTH ERUPTION,RESORPTION & REPLACEMENT

牙齿萌出、吸收的生物机制

• 批准号: 3434506
• 负责人: ZEEV DAVIDOVITCH
• 金额: $ 0.5万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-01 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434506
• 关键词: dental development; dental implants; dentistry; meeting /conference /symposium; tooth resorption; travel

The eruption of teeth and the resorption of their roots are phenomena associated with craniofacial growth and development. While the normal progression of these processes has been described in detail, a number of abnormalities exist, which are usually addressed by mechanical means. These abnormalities include eruption deviations in time and location, premature or delayed exfoliation of deciduous teeth, and tooth ankylosis. Root resorption is of particular concern during orthodontic tooth movement, and following dentoalveolar trauma. Dental implants are being used to replace missing teeth in adults, and as anchorage units in orthodontics. They are made of inert (e.g. titanium) or bioactive (e.g. hydroxyapatite) materials, and most achieve various degrees of osseointegration, which resembles ankylosis. However, in growing patients it may be desirable to use implants that do not osseointegrate, but rather develop a periodontal ligament-like structure that would permit implants to erupt. Recent reports suggest that mineralized and non-mineralized connective tissue growth and maintenance, and epithelial-mesenchymal interactions are regulated by autocrine and paracrine signals, as well as by molecules derived from the nervous, immune, and endocrine systems, and from the diet. Moreover, these tissues grow and remodel under the influence of physical stresses. The resulting strains may be pivotal in stimulating cells, maintaining tissue integrity, and regulating processes such as tooth eruption, root resorption, and implant-tissue integration. The overall objective of this conference is to promote discussions and to provide evidence on the biological nature, on the molecular-cellular levels, of tooth eruption, resorption, and replacement, with the conviction that such knowledge will strengthen our clinical capabilities. The aim of this conference is to assemble a group of investigators who are actively involved in research on tooth eruption, resorption, and replacement, and related areas of cell-cell and cell-matrix interactions; nervous, immune, and endocrine system interactions in the regulation of connective tissue metabolism, with emphasis on regulatory mechanisms of skeletal and dental cells. The conference will attempt to integrate general and specific biologic information with that related to tooth eruption, resorption, and replacement, in order to broaden and deepen our understanding of these developmental and clinical phenomena, and foster our ability to administer better therapeutic means to prevent and rectify abnormalities. The audience will consist of about 240 individuals. The conference's proceedings will be published and distributed to all participants, and to every dental school library in the world.

牙齿的萌出和牙根的吸收是一种现象 与颅面生长发育有关而正常 已经详细描述了这些过程的进展， 存在异常情况，通常通过机械方式解决。 这些异常包括喷发时间和地点的偏差， 乳牙过早或延迟脱落和牙齿强直。 牙根吸收是正畸治疗过程中需要特别关注的问题 运动，以及随后的牙槽创伤。牙科植入物正在 用于替换成人缺失的牙齿，并作为 南极洲。它们由惰性材料（例如钛）或生物活性材料（例如钛）制成。 羟基磷灰石）材料，并且大多数实现了不同程度的 骨整合，类似于关节强直。 然而，在成长中的患者中， 可能希望使用不与骨结合的植入物， 形成牙周韧带样结构， 爆发 最近的报告表明，矿化和非矿化结缔组织 组织生长和维持以及上皮-间充质相互作用是 受自分泌和旁分泌信号的调节， 来自神经，免疫和内分泌系统，以及来自 饮食.此外，这些组织生长和重塑的影响下， 身体压力由此产生的菌株可能是刺激 细胞，维持组织完整性，并调节过程， 牙齿萌出、牙根吸收和种植体组织整合。的 本次会议的总体目标是促进讨论， 提供了生物学本质的证据， 水平，牙齿萌出，吸收和更换，与 相信这些知识将加强我们的临床能力。 这次会议的目的是召集一组调查人员， 积极参与牙齿萌出、吸收和 替代以及细胞-细胞和细胞-基质相互作用的相关领域; 神经，免疫和内分泌系统的相互作用在调节 结缔组织代谢，重点是调节机制， 骨骼和牙齿细胞。会议将试图整合 与牙齿相关的一般和特定生物信息 喷发、再吸收和替换，以扩大和加深我们的 了解这些发展和临床现象，并促进 我们有能力管理更好的治疗手段，以防止和纠正 异常观众将包括约240人。的 会议记录将出版并分发给所有人 参与者，以及世界上每一个牙科学校的图书馆。