Chromatin regulation of neural stem cell multipotency

神经干细胞多能性的染色质调控

• 批准号: nhmrc : 1084352
• 负责人: A/Pr Anne Voss
• 金额: $ 50.42万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/chromatin-regulation-neural-cell-multipotency/519001
• 关键词: Chromatin; regulation; neural; stem; cell

The genetic material is packaged in the cell nucleus with histone proteins. Chemical modifications of histones determine if a particular area of the genome is active or repressed. We are investigating a family of histone modifying proteins, the MYST proteins. Mutations in these proteins cause intellectual disability and cancer. In this project we examine the role of MYST2 in brain stem cells. Knowledge gained may become the basis for the development of drugs to treat neurodegenerative disease.

遗传物质与组蛋白一起包装在细胞核中。组蛋白的化学修饰决定了基因组的特定区域是活跃的还是受抑制的。我们正在研究一个家族的组蛋白修饰蛋白，MYST蛋白。这些蛋白质的突变会导致智力残疾和癌症。在这个项目中，我们研究MYST 2在脑干细胞中的作用。所获得的知识可能成为开发治疗神经退行性疾病的药物的基础。