MOZ regulates cellular senescence
MOZ regulates cellular senescence
批准号:
nhmrc : 1084509
负责人:
A/Pr Anne Voss
金额:
$33.24万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
我们最近发现MOZ(单核细胞白血病锌指基因)是衰老的主要调节基因,该基因最先在导致一种特别侵袭性的白血病的r突变中被发现。在没有MoZ的情况下,细胞退出细胞周期,变得衰老,与DNA损伤无关。这些观察对于了解癌症的发展非常重要,因为癌症要生长和扩散,细胞必须避免衰老。
英文摘要
We have recently discovered that MOZ (monocytic leukaemia zinc finger gene), a gene first identified in rmutations leading to a particularly aggressive form of leukaemia, is a major regulator of senescence. In the absence of MOZ cells exit the cell cycle and become senescent, independently of DNA damage. These obsevations are very important for understanding cancer development because for cancer to grow and spread the cells must avoid senescence.
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Effects of the histone acetyltransferases MOZ and QKF on chromatin modifications
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Body segment identity specification by the transcription regulator, Moz
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