MOZ regulates cellular senescence

MOZ 调节细胞衰老

• 批准号: nhmrc : 1084509
• 负责人: A/Pr Anne Voss
• 金额: $ 33.24万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/moz-regulates-cellular-senescence/519012
• 关键词: MOZ; regulates; cellular; senescence

We have recently discovered that MOZ (monocytic leukaemia zinc finger gene), a gene first identified in rmutations leading to a particularly aggressive form of leukaemia, is a major regulator of senescence. In the absence of MOZ cells exit the cell cycle and become senescent, independently of DNA damage. These obsevations are very important for understanding cancer development because for cancer to grow and spread the cells must avoid senescence.

我们最近发现，MOZ（单核细胞白血病锌指基因）是衰老的主要调节因子，该基因首次在导致一种特别侵袭性白血病的突变中被发现。在缺乏MOZ的情况下，细胞退出细胞周期并变得衰老，而不受DNA损伤的影响。这些观察结果对于了解癌症的发展非常重要，因为癌症的生长和扩散必须避免细胞衰老。