The role of the suppressors of cytokine signalling 6 and 7 in cerebral cortex development

细胞因子信号6和7抑制剂在大脑皮层发育中的作用

• 批准号: nhmrc : 637346
• 负责人: A/Pr Anne Voss
• 金额: $ 25.15万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-suppressors-cytokine-cortex-development/80897
• 关键词: role; suppressors; cytokine; signalling; cerebral

Defects in neuronal cell migration during embryonic development lead to mental retardation and epilepsy. Although neuronal migration is essential for the development of normal intelligence, we know relatively little about the molecular mechanisms that regulate this process. We have identified two proteins, Socs6 and Socs7, which are essential for neuronal migration and normal cerebral cortex development. We propose to fully investigate the function of Socs6 and Socs7 during cortex development.

胚胎发育过程中神经细胞迁移的缺陷会导致智力迟钝和癫痫。虽然神经元迁移对于正常智力的发展至关重要，但我们对调节这一过程的分子机制知之甚少。我们已经确定了两种蛋白质，Socs6和Socs7，这是必不可少的神经元迁移和正常的大脑皮层发育。我们建议充分研究Socs6和Socs7在皮层发育过程中的功能。