Interaction between Moz and PRC1 in defining epigenetic states and gene expression patterns

Moz 和 PRC1 在定义表观遗传状态和基因表达模式方面的相互作用

• 批准号: nhmrc : 1008699
• 负责人: A/Pr Anne Voss
• 金额: $ 28.49万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interaction-moz-prc1-expression-patterns/109334
• 关键词: Interaction; between; Moz; PRC1; defining

Regulation of gene expression is implicated in all disease processes. Aberrant gene expression is particularly associated with tumour formation. In this project we determine the relationship between an oncogene MOZ and another oncogene BMI1. Together these proteins regulate one of the most important systems controlling gene expression at the level of chromatin structure.

基因表达的调节涉及所有疾病过程。异常基因表达与肿瘤形成特别相关。在这个项目中，我们确定癌基因MOZ和另一个癌基因BMI1之间的关系。这些蛋白质共同调节在染色质结构水平上控制基因表达的最重要系统之一。