Understanding the regulation of craniofacial development through control of chromatin and gene transcription

通过控制染色质和基因转录了解颅面发育的调节

• 批准号: nhmrc : 1051078
• 负责人: A/Pr Anne Voss
• 金额: $ 41.1万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-regulation-craniofacial-gene-transcription/112192
• 关键词: Understanding; regulation; craniofacial; development; through

Cleft lip and palate are among the most common birth defects. Key genes regulating palate development are sensitive to disturbance by environmental factors. We use this system to comprehensively determine a molecular pathway that is at the interface between the environment and gene transcription. Knowledge gained in the project will draw a framework for our understanding of how environmental insults affect chromatin configuration and gene expression and will inform the basis of measures to prevent birth defects.

唇裂和腭裂是最常见的出生缺陷之一。调控腭发育的关键基因对环境因素的干扰很敏感。我们使用这个系统来全面确定一个分子途径，是在环境和基因转录之间的接口。在该项目中获得的知识将为我们理解环境损伤如何影响染色质构型和基因表达绘制一个框架，并将为预防出生缺陷的措施提供依据。