Regulation of haematopoietic stem cells through histone modifications

通过组蛋白修饰调节造血干细胞

• 批准号: nhmrc : 1084248
• 负责人: A/Pr Anne Voss
• 金额: $ 53.14万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-haematopoietic-stem-histone-modifications/518990
• 关键词: Regulation; haematopoietic; stem; cells; through

The genetic material is packaged in the cell nucleus with histone proteins. Modifications of histones determine if a particular area of the genome is active or repressed. We are investigating a family of histone modifying proteins, the MYST proteins. Mutations in these proteins cause intellectual disability and blood cancer. In this project we examine the role of MYST2 in blood stem cells. Knowledge gained may become the basis for the development of drugs for the treatment of cancer.

遗传物质用组蛋白包裹在细胞核中。组蛋白的修饰决定了基因组的某个特定区域是活跃的还是被抑制的。我们正在研究一个组蛋白修饰蛋白家族，MYST蛋白。这些蛋白质的突变会导致智力残疾和血癌。在这个项目中，我们研究MYST2在血液干细胞中的作用。所获得的知识可能成为开发治疗癌症的药物的基础。