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Multifunctional Gel Scaffolds for Cell Delivery and Tissue Repair

用于细胞递送和组织修复的多功能凝胶支架

基本信息

批准号：
EP/M02881X/1
负责人：
Silviya Halacheva
金额：
$ 12.72万
依托单位：
University of Bolton
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FM02881X%2F1
关键词：
Multifunctional Gel Scaffolds Cell Delivery

项目摘要

Injectable biomaterial scaffolds for tissue reconstruction are still not a clinical reality because many of the scaffold design parameters have not been fully optimized and controlled. New multifunctional scaffolds that both mimic the mechanical properties and structure of natural tissues and are able to promote cell adhesion, proliferation and differentiation are now urgently needed. The aim of this project is to develop new hyper-branched poly(glycidol)/poly(caprolactam) (HBPG/PCL) based injectable gel scaffolds that have the potential to enable bone growth and the regeneration of cartilage in vivo, following application in a minimally invasive manner. They will thereby enable effective treatment of osteoarthritis (OA) without surgery. OA is characterized pathologically by localised loss of cartilage, remodeling of adjacent bone and associated inflammation. OA is one of the leading causes of pain and disability worldwide. New covalently-linked scaffolds that exhibit gradually increasing mechanical strength will be formed in vivo from physically cross-linked HBPG/PCL particles in a safe and effective way, in the absence of UV-radiation. They will feature tunable elastic modulus values and will undergo enzyme-triggered disassembly. The proposal will benefit the NHS by improving patients' quality of life, reducing surgical costs and boost the UK economy by shortening patient recovery times and reducing productivity losses due to disability and/or illness. The proposal greatly extends Dr. Halacheva's earlier studies on biomaterials scaffolds and will be conducted by a postdoctoral research associate (PDRA) and a University of Bolton funded Ph.D. student over a period of 15 months.

可注射生物材料支架用于组织重建仍不是临床现实，因为许多支架设计参数还没有得到充分的优化和控制。现在迫切需要一种新型的多功能支架，既能模拟自然组织的力学性能和结构，又能促进细胞的黏附、增殖和分化。该项目的目的是开发新型超支化聚缩水甘油/聚己内酰胺(HBPG/PCL)可注射凝胶支架，在以微创方式应用后，具有在体内实现骨生长和软骨再生的潜力。因此，它们将使无需手术即可有效治疗骨关节炎(OA)成为可能。骨性关节炎的病理特征是局部软骨丢失、邻近骨骼重塑和相关的炎症。骨性关节炎是世界范围内导致疼痛和残疾的主要原因之一。在没有紫外线辐射的情况下，由物理交联的HBPG/PCL粒子在体内安全有效地形成新的共价连接支架，显示出逐渐增强的机械强度。它们将具有可调的弹性模量值，并将经过酶触发的拆卸。该提案将提高患者的生活质量，降低手术成本，并通过缩短患者康复时间和减少因残疾和/或疾病造成的生产力损失来提振英国经济，从而使NHS受益。该提案极大地扩展了Halacheva博士早期对生物材料支架的研究，将由博士后助理研究员(PDRA)和博尔顿大学资助的一名博士生进行为期15个月的研究。