BIOCOMPATIBILITY OF SYNTHETIC LENSES - PHASE I

隐形眼镜的便利性和光学优势正在产生一种 加长服和日用服装产品的市场不断增长。一种需要 有待改进两种接触方式的生物相容性(特别是 长期配戴)和人工晶状体。在许多用户中，长期佩戴的接触 镜片过快会失去光学清晰度和舒适性 眼睛对蛋白质、钙和其他次要成分的吸收 体液和组织。气体的改进或维护(特别是氧气) 渗透性和与角膜的非损伤性相互作用，是 长时间佩戴隐形眼镜。汽车防腐涂料的研制 人工晶状体通过与角膜接触减少角膜损伤 手术时角膜受损，也是目前的需要。这个 国家眼科研究所认识到这些对技术发展的需求 并要求在PHS中提出小企业创新研究建议 综合征集(简写为SBIR)。塑料表面的化学“剪裁” 通过光化学耦合已经在我们的实验室中被证明 成为生物相容性控制的有效方法。通过高效 光化学耦合在非常温和的反应条件下，表面 许多塑料的化学性质已经通过 中性亲水或疏水聚合物的共价连接， 蛋白质和其他带电或其他官能团。初步 亲水性聚合物衍生物的光化学吸附研究 到聚苯乙烯、聚亚安酯和聚氯乙烯表面 聚(甲基丙烯酸羟乙酯)的降粘率显著降低。 加入少量蛋白质的自发吸附。 Bio-Metric Systems提出了一个测试实验可行性的计划 通过改善接触镜和人工晶状体的生物相容性 其表面的光化学附着亲水性和其他 化学侧链带有所需的化学、静电等 功能属性。

The convenience and optical advantages of contact lenses are producing a growing market for both the extended-wear and daily-wear products. A need remains for improvements in the biocompatibility of both contact (esp. long-wear) and intraocular lenses. In many users, the long-wear contact lenses lose optical clarity and comfort through excessively rapid adsorption of proteins, calcium and other minor components from the eye fluid and tissue. The improvement or maintenance of gas (esp. oxygen) permeability and non-injurious interaction with the cornea, is needed for long-wear contact lens. The development of protective coating for intraocular lenses to decrease corneal damage through contact with the damaged cornea at the time of surgery, also remains a current need. The National Eye Institute recognizes these needs for technology development and has requested small business innovative research proposals in the PHS Omnibus Solicitation-SBIR. The chemical "tailoring" of plastic surfaces through photochemical coupling has been demonstrated in our laboratories to be a productive approach to biocompatibility control. Through efficient photochemical coupling under very gentle reaction conditions, the surface chemical properties of numerous plastics have been modified through covalent attachment of neutral hydrophilic or hydrophobic polymers, proteins and other charged or otherwise functional groups. Preliminary studies on the photochemical attachment of hydrophilic polymer derivatives to the surface of polystyrene, polyurethane and poly(hydroxyethylmethacrylate), have demonstrated a major decrease in the spontaneous adsorption of a few proteins added. Bio-Metric Systems presents a plan for testing the experimental feasibility of biocompatibility improvements on contact and intraocular lenses through the photochemical attachment to their surfaces of hydrophilic and other chemical side chains with the desired chemical, electrostatic and other functional properties.