Advanced Mass Spectrometry Kit for Controlling Chemical Robots and Exploring Complex Chemical Systems

用于控制化学机器人和探索复杂化学系统的先进质谱套件

• 批准号: EP/P00153X/1
• 负责人: Leroy Cronin
• 金额: $ 100.64万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP00153X%2F1
• 关键词: Advanced; Mass; Spectrometry; Kit; Controlling

We will use this kit to help us establish a world leading and unique capability for exploring real-time feedback control driven by very high resolution MS in the area of chemical cybernetics / chemical robotics. The emerging field of Chemical Cybernetics aims to build upon existing expertise in chemical robotics, complex networks, supramolecular self-assembly and automation, combined with newly available state-of-the-art chromatographic and mass spectrometric techniques to drive feedback control and artificial intelligence in complex chemical systems. The equipment requested in this proposal will allow the construction of a truly unique platform where advanced spectrometric techniques, usually only seen in metabolomics, are applied to chemical problems of low-abundance analyte identification and differentiation of complex mixtures over a broad spectrum of research, from optimisation of automated synthesis for a 'dial-a-molecule' devices to sequence specification in origins of life research to manufacturing and chemical discovery.

我们将使用该工具包帮助我们在化学控制论/化学机器人领域建立世界领先的独特能力，探索由非常高分辨率的MS驱动的实时反馈控制。化学控制论的新兴领域旨在建立在化学机器人、复杂网络、超分子自组装和自动化方面的现有专业知识的基础上，结合最新可用的最先进的色谱和质谱学技术，以推动复杂化学系统中的反馈控制和人工智能。该提案中所要求的设备将允许建立一个真正独特的平台，在这个平台上，通常只在代谢组学中才能看到的先进光谱技术被应用于低丰度分析物的鉴定和复杂混合物的区分等广泛研究中的化学问题，从‘拨号分子’设备的自动合成的优化到生命起源研究的序列规范到制造和化学发现。

项目成果

A recursive microfluidic platform to explore the emergence of chemical evolution.

探索化学进化出现的递归微流体平台。

• DOI: 10.3762/bjoc.13.164
• 发表时间: 2017
• 期刊: Beilstein journal of organic chemistry
• 影响因子: 2.7
• 作者: Doran D;Rodriguez-Garcia M;Turk-MacLeod R;Cooper GJT;Cronin L
• 通讯作者: Cronin L

Taming the Combinatorial Explosion of the Formose Reaction via Recursion within Mineral Environments

• DOI: 10.1002/syst.201900014
• 发表时间: 2019-09-01
• 期刊: CHEMSYSTEMSCHEM
• 作者: Colon-Santos, Stephanie;Cooper, Geoffrey J. T.;Cronin, Leroy
• 通讯作者: Cronin, Leroy

A robotic prebiotic chemist probes long term reactions of complexifying mixtures.

• DOI: 10.1038/s41467-021-23828-z
• 发表时间: 2021-06-10
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Asche S;Cooper GJT;Keenan G;Mathis C;Cronin L
• 通讯作者: Cronin L

Exploring the sequence space of unknown oligomers and polymers

探索未知低聚物和聚合物的序列空间

• DOI: 10.1016/j.xcrp.2021.100685
• 发表时间: 2021
• 期刊: Cell Reports Physical Science
• 影响因子: 8.9
• 作者: Doran D

A Portable 3D Printer System for the Diagnosis and Treatment of Multidrug-Resistant Bacteria

• DOI: 10.1016/j.chempr.2016.08.008
• 发表时间: 2016-09
• 期刊: Chem
• 影响因子: 23.5
• 作者: S. Glatzel;M. Hezwani;Philip J. Kitson;P. Gromski;Sophie Schürer;L. Cronin