Atmospheric pressure plasma assisted synthesis of multi-functional bionanocomposites

常压等离子体辅助合成多功能生物纳米复合材料

• 批准号: EP/P00394X/1
• 负责人: Dan Sun
• 金额: $ 12.83万
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP00394X%2F1
• 关键词: Atmospheric; pressure; plasma; assisted; synthesis

Cancer is one of the leading causes of death worldwide. The total economic cost of cancer in the EU was more than £99 billion in 2009 [1] and the cost of diagnosing and treating cancer in the UK is expected to reach £15.3 billion by 2021 [2]. Conventional cancer surgery treatment suffers from various complications such as pain, damage to nearby tissues and possible thrombosis. Other common cancer therapies, such as chemotherapy, have the limitation of drug resistance, lack of selectivity, and lack of solubility. Given these issues associated with treatment safety and effectiveness, scientists are applying tremendous efforts towards new approaches in the fight against cancer. The use of nanotechnology in cancer treatment offers some exciting possibilities.The proposed research involves innovation and collaboration among cross-disciplinary experts (materials science, physics and cancer research) to resolve some of the major challenges in the application of nanotechnology to cancer. The PI proposes to develop a novel technology that allows incorporation of magnetic nanoparticles (NP) into a hydrogel without using toxic chemicals or surfactants, while ensuring the NP dispersion and stability. The resulting material will be an injectable "smart" system useful for certain cancer treatment, with multiple functions including 1) controlled drug delivery 2) inducing heat under an externally applied magnetic field and 3) facilitating bio-imaging. [1] Luengo-Fernandez, R., et al., Economic burden of cancer across the European Union: a population-based cost analysis. The Lancet Oncology, 2013. 14(12): p. 1165-1174.[2] Bupa Cancer diagnosis and treatment: a 2021 projection.

癌症是全球主要的死亡原因之一。2009年，欧盟癌症的总经济成本超过990亿英镑[1]，到2021年，英国诊断和治疗癌症的成本预计将达到153亿英镑[2]。传统的癌症手术治疗遭受各种并发症，例如疼痛、对附近组织的损伤和可能的血栓形成。其他常见的癌症治疗，如化疗，具有耐药性的限制，缺乏选择性，缺乏溶解性。考虑到这些与治疗安全性和有效性相关的问题，科学家们正在为对抗癌症的新方法付出巨大努力。纳米技术在癌症治疗中的应用提供了一些令人兴奋的可能性。拟议的研究涉及跨学科专家（材料科学，物理学和癌症研究）之间的创新和合作，以解决纳米技术应用于癌症的一些主要挑战。PI建议开发一种新技术，允许将磁性纳米颗粒（NP）掺入水凝胶中，而不使用有毒化学品或表面活性剂，同时确保NP的分散性和稳定性。由此产生的材料将是一种可注射的“智能”系统，可用于某些癌症治疗，具有多种功能，包括1）控制药物输送，2）在外部施加的磁场下诱导热量，3）促进生物成像。[1]Luengo-Fernandez河，例如，欧盟癌症的经济负担：基于人口的成本分析《柳叶刀肿瘤学》，2013年。14（12）：第1165-1174页。[2]保柏癌症诊断和治疗：2021年预测。

项目成果

Metal nanoparticle-hydrogel nanocomposites for biomedical applications - An atmospheric pressure plasma synthesis approach

• DOI: 10.1002/ppap.201800112
• 发表时间: 2018-11-01
• 期刊: PLASMA PROCESSES AND POLYMERS
• 影响因子: 3.5
• 作者: Nolan, Hugo;Sun, Daye;Sun, Dan
• 通讯作者: Sun, Dan

Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications

纳米级混合涂层使多功能组织支架能够用于潜在的多模式治疗应用

• DOI: 10.1021/acsami.9b04278
• 发表时间: 2019-07-31
• 期刊: ACS APPLIED MATERIALS & INTERFACES
• 影响因子: 9.5
• 作者: Guo, Zhijun;Jiang, Nan;Sun, Dan
• 通讯作者: Sun, Dan

A fast UV-curable PU-PAAm hydrogel with mechanical flexibility and self-adhesion for wound healing.

一种快速紫外线固化 PU-PAAm 水凝胶，具有机械灵活性和自粘性，可促进伤口愈合

• DOI: 10.1039/c9ra10666a
• 发表时间: 2020-01-29
• 期刊: RSC advances
• 影响因子: 3.9

Smart multi-layer PVA foam/ CMC mesh dressing with integrated multi-functions for wound management and infection monitoring

• DOI: 10.1016/j.matdes.2020.108913
• 发表时间: 2020-09-01
• 期刊: MATERIALS & DESIGN
• 影响因子: 8.4
• 作者: He, Miaomiao;Ou, Feiyang;Zhang, Li
• 通讯作者: Zhang, Li

Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-drug Release, Antimicrobial, and Photothermal Conversion Functions

具有多药物释放、抗菌和光热转换功能的壳聚糖/纳米银/氧化石墨烯纳米复合材料

• DOI: 10.20944/preprints202104.0311.v1
• 发表时间: 2021
• 作者: Su Z