Harnessing the potential of metals in biocatalysis

利用金属在生物催化中的潜力

• 批准号: DP150104358
• 负责人: Prof David Ollis
• 金额: $ 29.6万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104358
• 关键词: Harnessing; potential; metals; biocatalysis

The project aims to use an integrated, multi-disciplinary approach to study the properties of a group of related but functionally diverse enzymes; binuclear metallohydrolases (BMHs). These enzymes are of great relevance to protein engineers aiming to produce potent agents for bioremediation and pharmacologists interested in developing drugs. Elucidating and modulating the mode of action of BMHs is thus our main objective and should provide essential information to fully exploit the potential of these enzymes for practical applications. In particular, understanding how metal ions interact with BMHs and how this contributes to their reactivity is crucial to optimally understand their biotechnological potential.

该项目旨在使用综合的多学科方法来研究一组相关但功能多样的酶的性质;双核金属水解酶（BMHs）。这些酶与旨在生产生物修复有效试剂的蛋白质工程师和对开发药物感兴趣的药理学家具有很大的相关性。因此，阐明和调节BMH的作用模式是我们的主要目标，并应提供必要的信息，以充分利用这些酶的实际应用潜力。特别是，了解金属离子如何与BMH相互作用，以及这如何有助于它们的反应性，对于最佳地了解它们的生物技术潜力至关重要。