Harnessing the potential of metals in biocatalysis

该项目旨在使用一种综合的、多学科的方法来研究一组相关但功能不同的酶：双核金属水解酶(BMHs)的性质。这些酶对于致力于生产用于生物修复的有效药物的蛋白质工程师和对开发药物感兴趣的药理学家来说非常重要。因此，阐明和调节BMHs的作用方式是我们的主要目标，并应为充分开发这些酶的实际应用潜力提供必要的信息。特别是，了解金属离子如何与BMHs相互作用以及这如何有助于它们的反应活性，对于最佳地了解它们的生物技术潜力至关重要。

The project aims to use an integrated, multi-disciplinary approach to study the properties of a group of related but functionally diverse enzymes; binuclear metallohydrolases (BMHs). These enzymes are of great relevance to protein engineers aiming to produce potent agents for bioremediation and pharmacologists interested in developing drugs. Elucidating and modulating the mode of action of BMHs is thus our main objective and should provide essential information to fully exploit the potential of these enzymes for practical applications. In particular, understanding how metal ions interact with BMHs and how this contributes to their reactivity is crucial to optimally understand their biotechnological potential.