IN VIVO 17O NMR STUDIES OF CEREBRAL OXYGEN CONSUMPTION AND BLOOD FLOW

脑耗氧量和血流量的体内 17O NMR 研究

• 批准号: 3789494
• 负责人: A C MCLAUGHLIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789494
• 关键词: blood flow measurement; brain imaging /visualization /scanning; brain metabolism; method development; nuclear magnetic resonance spectroscopy; oxygen; oxygen consumption; stable isotope

This project involves the development of new non-invasive approaches for imaging oxygen consumption and blood flow in the brain. These new approaches combine the advantages of magnetic resonance spectroscopy, which can separate signals from different metabolites or "tracers" in the brain, and magnetic resonance imaging, which can localize signals from metabolites and tracers to well-defined regions of the brain. If 170- labeled water, which is the end product of oxidative metabolism in the brain. If the blood flow is also imaged, the rate of increase in the 170- labelled water signal can be used to calculate the rate of oxygen consumption. In the last year we have shown that 19F NMR techniques can be used to image cerebral blood flow with a spatial resolution of 0.4 cc, which is approximately the same spatial evolution as PET. We have also shown that 19F NMR approaches can be combined with 170 NMR approaches to image simultaneously cerebral blood flow and oxygen consumption. The 170 NMR approach is very similar to the 150 PET approach for imaging cerebral oxygen consumption and blood flow. At the present time, the spatial resolution of the 170 approach is 0.8 cc, which is not as good as the spatial resolution of 150 PET (approximately 0.5 cc). However, the 170 NMR approach has two important advantages: first, 170-labeled compounds are non-radioactive and non-toxic, and second, the interpretation of 170 spectroscopic data is much simpler than the interpretation of 150 PET data.

该项目涉及开发新的非侵入性方法， 对大脑的耗氧量和血流进行成像。 这些新 这些方法联合收割机结合了磁共振波谱的优点， 它可以从不同的代谢物或“示踪剂”中分离信号， 大脑和磁共振成像，可以定位信号， 代谢物和示踪剂到大脑的明确区域。 如果170- 标记的水，这是最终产品的氧化代谢， 个脑袋 如果血流也被成像，则170- 180度的增加率可以被测量。 标记的水信号可用于计算氧的速率 消费 在过去的一年里，我们已经证明，19 F NMR技术可以 用于以0.4cc的空间分辨率对脑血流成像， 这与PET的空间演化大致相同。 我们还 表明19 F NMR方法可以与170 NMR方法结合， 同时成像脑血流量和氧消耗。 的170 NMR方法与150 PET脑成像方法非常相似 氧气消耗和血液流动。 目前，空间 170方法的分辨率为0.8 cc，这不如 空间分辨率为150 PET（约0.5 cc）。 然而，170 核磁共振方法有两个重要的优点：一是170标记化合物 第一，无放射性，无毒，第二，解释170 光谱数据比150 PET的解释简单得多 数据