ELECTROSTATIC PROPERTIES OF MEMBRANE

膜的静电特性

• 批准号: 3801925
• 负责人: A C MCLAUGHLIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3801925
• 关键词: calcium; cations; cell growth regulation; cell membrane; hydrogen; ionic bond; magnesium; membrane activity; membrane lipids; membrane potentials; phosphatidylinositols; potassium

The surface potential of cellular membranes is an important determinant in the physiological function of the cell. We have investigated a number of factors that affect the surface potential of membranes. We have also modified the theory that has been used to calculate the surface potential, the Gouy-Chapman theory, to account for these factors. Triphosphoinositide lipids in plasma membranes could have up to five negative charges. We previously investigated the interaction of calcium, magnesium, potassium, protons and other cations with triphosphoinositides, and determined the number of cations bound to the lipid under physiologically-relevant conditions. We also investigated proton titration curves of the lipid and found that there was a cooperative interaction between the two monoester groups in the inositol headgroup. We proposed that this interaction could have important consequences in terms of the net charge on the triphosphoinositide lipid under physiological conditions.

细胞膜的表面电位是一个重要的决定因素 细胞的生理功能。 我们已经研究了 影响膜表面电位的因素很多。 我们 还修改了用于计算 表面电位，Gouy-Chapman理论，来解释这些 因素 质膜中的三磷酸肌醇脂质可能含有多达五个 负电荷。 我们之前研究了钙， 镁、钾、质子和其它阳离子， 三磷酸肌醇，并确定了阳离子结合的数量， 在生理相关条件下的脂质。 我们还调查 质子滴定曲线的脂质，并发现有一个 肌醇中两个单酯基团之间的协同相互作用 领导小组。 我们认为这种互动可能具有重要意义 三磷酸肌醇脂质上的净电荷的结果 在生理条件下。