IN VIVO 170 NMR STUDIES OF CEREBRAL OXYGEN CONSUMPTION

脑耗氧量的体内 170 NMR 研究

• 批准号: 3801936
• 负责人: A C MCLAUGHLIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3801936
• 关键词: brain imaging /visualization /scanning; noninvasive diagnosis; nuclear magnetic resonance spectroscopy; oxygen; oxygen consumption

This project involves the development of a new non-invasive approach for imaging oxygen consumption in the brain. This new approach combines the advantages of magnetic resonance spectroscopy, which can separate signals from different metabolites in the brain, and magnetic resonance imaging, which can localize signals to well-defined regions of the brain. If 17O-labelled oxygen is inhales, 17O NMR spectroscopy can separate and quantitate signals from 17O-labelled water, which is the end product of oxidative metabolism in the brain. The rise of this signal directly gives the rate of oxygen consumption in the brain. If this signal is imaged, the rate of oxygen consumption in different regions of the brain can be determined. At the present time, the spatial resolution of the approach is 0.8 cc. One of the major advantages of the 17O NMR approach is that NMR techniques are non-invasive, and can be used with humans, and that 17O-labelled compounds, i.e., oxygen and water, are non-radioactive, and non-toxic.

该项目涉及开发一种新的非侵入性方法 来成像大脑的耗氧量。 这种新方法 结合了磁共振波谱的优点， 分离大脑中不同代谢物的信号， 共振成像，它可以定位信号到明确的区域， 大脑 如果吸入17O标记的氧，17O NMR光谱可以分离 并对来自17O标记水的信号进行定量， 大脑中氧化代谢的产物。 这个信号的出现 直接给出了大脑的耗氧率 如果这 信号被成像，不同区域的耗氧率 大脑的活动是可以确定的。 目前，空间 该方法的分辨率为0.8cc。 17O NMR方法的主要优点之一是NMR 技术是非侵入性的，可以用于人类， 17O标记的化合物，即，氧气和水，是非放射性的， 无毒。