CEREBRAL BLOOD FLOW AND ENERGY METABOLISM IN THE RAT

大鼠脑血流量和能量代谢

• 批准号: 3801924
• 负责人: A C MCLAUGHLIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3801924
• 关键词: alcoholism /alcohol abuse; bioenergetics; biological models; cerebral ischemia /hypoxia; cerebrovascular disorder diagnosis; drug withdrawal; hormone regulation /control mechanism; hypercapnia; hypoglycemia; laboratory rat; model design /development; neurotransmitters; pituitary adrenal axis; stress; sympathetic nervous system

The role of humoral and neuronal factors in the control of cerebral blood flow and metabolism is controversial. We have studied the role of the adrenal/hypophysis axis and the role of sympathetic activation on cerebral blood flow and metabolism under normal and stressful conditions. Our initial work has been done with the hypercapnic model for stress, but the studies will be extended to other models for stress, e.g., hypoxia, hypoglycemia and withdrawal from chronic alcohol consumption.

体液和神经因子在脑缺血性脑损伤控制中的作用 血液流动和新陈代谢是有争议的。 我们研究了 肾上腺/垂体轴和交感神经激活的作用 对正常和应激状态下脑血流和代谢的影响 条件 我们最初的工作是用高碳酸血症模型完成的 但这些研究将扩展到其他压力模型， 例如，在一个实施例中，缺氧、低血糖和长期戒酒 消费