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CEREBRAL BLOOD FLOW AND ENERGY METABOLISM IN THE RAT

CEREBRAL BLOOD FLOW AND ENERGY METABOLISM IN THE RAT
大鼠脑血流量和能量代谢
批准号：
3808631
负责人：
A C MCLAUGHLIN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3808631
关键词：
alcoholic beverage consumption bioenergetics cerebral ischemia /hypoxia cerebrovascular disorder diagnosis diagnosis design /evaluation disease /disorder model drug adverse effect drug withdrawal glucose metabolism hormone regulation /control mechanism hypercapnia hypoglycemia laboratory rat neurohormones neurotransmitters oxygen consumption pituitary adrenal axis stress sympathetic nervous system

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英文摘要
The role of humoral and neuronal factors in the control of cerebral blood flow and metabolism is controversial. We have studied the role of the adrenal/hypophysis axis and the role of sympathetic activation on cerebral blood flow and metabolism under normal and stressful conditions. Our initial work has been done with the hypercapnic model for stress, but the studies will be extended to other models for stress, e.g., hypoxia, hypoglycemia and withdrawal from chronic alcohol consumption.
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