STUDIES OF PATIENTS WITH IMMUNE-MEDIATED DISEASES

对免疫介导疾病患者的研究

• 批准号: 3810924
• 负责人: A D STEINBERG
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3810924
• 关键词: Retroviridae; Retroviridae disease; antibody formation; autoimmune disorder; gene expression; human subject; immunopathology diagnosis; immunoregulation; leukocytes; messenger RNA; nucleic acid hybridization; nucleic acid probes; tissue /cell culture; virus genetics

mRNA hybridizing with probes specific for human endogenous retroviruses has been detected in leukocytes from patients with autoimmune diseases and normal individuals. We have used additional probes not available to us last year; however, we still do not have probes comparable to those used in the murine studies. Additional studies need to be performed with more specific subclass probes to determine whether or not there is disease specific expression.

mRNA与人内源性逆转录病毒特异性探针杂交， 在自身免疫性疾病患者的白细胞中检测到， 正常的个体。我们已经使用了额外的探头， 年;然而，我们仍然没有可与 小鼠研究。需要进行更多的研究， 亚类探针，以确定是否存在疾病特异性 表情