THERAPEUTIC STUDIES IN MURINE LUPUS

富含多不饱和脂肪酸，二十碳五烯酸的饮食 酸，显着延缓（NZB）自身免疫的发展 x NZW）F1代雌性。 这甚至在疾病发作后也有效。 目前正在进行人体试验。 环磷酰胺是有效的治疗各种 与疾病的细胞基础无关的自身免疫性菌株，或 增殖细胞的性质（B或T细胞）。 这种疗法 对MRL-lpr/lpr的淋巴结病有效， C3 H/HeJ-gld/gld小鼠与BXSB的冠状动脉病变 和（NZW x BXSB）F1小鼠以及大多数 鼠狼疮的例子。 环磷酰胺显著降低 MRL-lpr/lpr小鼠淋巴结中myb RNA升高， 增加非常低的胸腺MyB表达。 环孢素A是一种干扰T细胞功能的药物， 有效治疗关节炎、肾炎和 MRL-lpr/lpr小鼠的淋巴细胞增殖。 用TNF处理（NZB x NZW）F1和MRL-lpr/lpr小鼠， 在生命早期或发病后开始有效 疾病

A diet enriched in a polyunsaturated fatty acid, eicosapentaenoic acid, markedly retards the development of autoimmunity in (NZB x NZW)F1 females. This works even after the onset of disease. Human trials are being carried out. Cyclophosphamide is effective treatment in a variety of autoimmune strains unrelated to the cellular basis of illness or the nature (B or T cell) of the proliferating cells. This therapy is effective against the lymphadenopathy of MRL-lpr/lpr and C3H/HeJ-gld/gld mice and the coronary artery disease of BXSB and (NZW x BXSB)F1 mice as well as the renal disease of most examples of murine lupus. Cyclophosphamide markedly reduces the elevated myb RNA in MRL-lpr/lpr mice lymph nodes and increases the very low thymic myb expression. Cyclosporin A, a drug which interferes with T cell function, is effective treatment for the arthritis, nephritis, and lymphoproliferation of MRL-lpr/lpr mice. Treatment of (NZB x NZW)F1 and MRL-lpr/lpr mice with TNF is effective when started either early in life or after the onset of disease.