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THERAPEUTIC STUDIES IN MURINE LUPUS

THERAPEUTIC STUDIES IN MURINE LUPUS
小鼠狼疮的治疗研究
批准号：
4689947
负责人：
A D STEINBERG
金额：
$0.0万
依托单位：
NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4689947
关键词：
animal mortality antinuclear autoantibody antiviral agents arachidonate autoimmune disorder cyclophosphamide dietary constituent dietary lipid dihydrotestosterone disease /disorder model drug screening /evaluation gender difference genetic strain glomerulonephritis immune complex diseases immunogenetics immunosuppressive marine animal oil nutrition related tag omega 3 fatty acid orphan disease /drug proteinuria sex hormones systemic lupus erythematosus testosterone thymectomy unsaturated fatty acids

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中文摘要
翻译
富含多不饱和脂肪酸二十碳五烯酸的饮食， 显著延缓(NZBxNZW)F1雌性小鼠自身免疫的发生。 即使在疾病发作之后，这也是有效的。人体试验正在进行中 出去。 环磷酰胺是治疗多种自身免疫性菌株的有效药物 与疾病的细胞基础或其性质(B或T细胞)无关 正在增殖的细胞。这种疗法对治疗高血压病有效 MRL-LPR/LPR和C3H/HeJ-GLD/GLD小鼠的淋巴病变与冠状动脉 BXSB和(NZWxBXSB)F1小鼠的动脉疾病和肾脏疾病 大多数小鼠狼疮的例子。环磷酰胺显著降低了 MYB RNA在MRL-LPR/LPR小鼠淋巴结中的升高和极低水平的增加 胸腺MYB的表达。
英文摘要
A diet enriched in a polyunsaturated fatty acid, eicosapentaenoic acid, markedly retards the development of autoimmunity in (NZBxNZW)F1 females. This works even after the onset of disease. Human trials are being carried out. Cyclophosphamide is effective treatment in a variety of autoimmune strains unrelated to the cellular basis of illness or the nature (B or T cell) of the proliferating cells. This therapy is effective against the lymphadenopathy of MRL-lpr/lpr and C3H/HeJ-gld/gld mice and the coronary artery disease of BXSB and (NZWxBXSB)F1 mice as well as the renal disease of most examples of murine lupus. Cyclophosphamide markedly reduces the elevated myb RNA in MRL-lpr/lpr mice lymph nodes and increases the very low thymic myb expression.
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会议论文
ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES
PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
VARIOUS CYTOTOXIC DRUG PROGRAMS IN DIFFUSE LUPUS NEPHRITIS
IMMUNE ABNORMALITIES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS