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THERAPEUTIC STUDIES IN MURINE LUPUS

THERAPEUTIC STUDIES IN MURINE LUPUS
小鼠狼疮的治疗研究
批准号：
4689947
负责人：
A D STEINBERG
金额：
$0.0万
依托单位：
NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4689947
关键词：
animal mortality antinuclear autoantibody antiviral agents arachidonate autoimmune disorder cyclophosphamide dietary constituent dietary lipid dihydrotestosterone disease /disorder model drug screening /evaluation gender difference genetic strain glomerulonephritis immune complex diseases immunogenetics immunosuppressive marine animal oil nutrition related tag omega 3 fatty acid orphan disease /drug proteinuria sex hormones systemic lupus erythematosus testosterone thymectomy unsaturated fatty acids

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英文摘要
A diet enriched in a polyunsaturated fatty acid, eicosapentaenoic acid, markedly retards the development of autoimmunity in (NZBxNZW)F1 females. This works even after the onset of disease. Human trials are being carried out. Cyclophosphamide is effective treatment in a variety of autoimmune strains unrelated to the cellular basis of illness or the nature (B or T cell) of the proliferating cells. This therapy is effective against the lymphadenopathy of MRL-lpr/lpr and C3H/HeJ-gld/gld mice and the coronary artery disease of BXSB and (NZWxBXSB)F1 mice as well as the renal disease of most examples of murine lupus. Cyclophosphamide markedly reduces the elevated myb RNA in MRL-lpr/lpr mice lymph nodes and increases the very low thymic myb expression.
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ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES
PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
VARIOUS CYTOTOXIC DRUG PROGRAMS IN DIFFUSE LUPUS NEPHRITIS
IMMUNE ABNORMALITIES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS