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PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS

PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
患有系统性红斑狼疮样疾病的小鼠自身免疫的发病机制
批准号：
3819290
负责人：
A D STEINBERG
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3819290
关键词：
B lymphocyte Retroviridae antibody formation autoantibody autoimmune disorder disease /disorder model gene expression genetic transcription immunogenetics laboratory mouse leukocyte activation /transformation linkage mapping molecular pathology systemic lupus erythematosus

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中文摘要
翻译
抗体产生细胞的研究，包括自身抗体
英文摘要
Studies of antibody producing cells, including autoantibody producing cells, demonstrate that murine lupus is initiated by polyclonal B cell activation which is followed by preferential (probably antigen-dependent and T cell dependent) autoantibody production. All of the autoimmune mouse strains but not most normal strains of mice express full-length (8.4 kb) MCF retroviral transcripts in thymus, and spleen. NZB mice have such transcripts from birth suggesting that they do not result from disease. Polyclonal immune activators can induce at least one such 8.4 kb MCF retroviral transcript in NFS mice; however, additional transcript(s) are found in the unstimulated autoimmune mice. The gld gene has been mapped to a region of distal mouse chromosome 1 which is syntatic with human chromosome 1 and with close linkage to AT3.
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ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES
PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
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