THERAPEUTIC STUDIES IN MURINE LUPUS

一种富含多不饱和脂肪酸，二十碳五烯酸， 显著延缓（NZB x NZW）F1中自身免疫的发展 女性 这甚至在疾病发作后也有效。 人体试验 正在执行。 环磷酰胺是有效的治疗在各种自身免疫性菌株 与疾病的细胞基础或疾病的性质（B或T细胞）无关。 增殖的细胞。 这种疗法是有效的， MRL-lpr/lpr和C3 H/HeJ-gld/gld小鼠的淋巴结病和冠状动脉 BXSB和（NZW x BXSB）F1小鼠的动脉疾病以及肾脏疾病 大多数鼠狼疮的例子。 环磷酰胺显著降低了 MRL-lpr/lpr小鼠淋巴结中myb RNA的升高，并增加了非常低的 胸腺myb表达。 环孢素A是一种干扰T细胞功能的药物， 治疗关节炎、肾炎和淋巴增生 MRL-lpr/lpr小鼠。

A diet enriched in a polyunsaturated fatty acid, eicosapentaenoic acid, markedly retards the development of autoimmunity in (NZB x NZW) Fl females. This works even after the onset of disease. Human trials are being carried out. Cyclophosphamide is effective treatment in a variety of autoimmune strains unrelated to the cellular basis of illness or the nature (B or T cell) of the proliferating cells. This therapy is effective against the lymphadenopathy of MRL-lpr/lpr and C3H/HeJ-gld/gld mice and the coronary artery disease of BXSB and (NZW x BXSB)F1 mice as well as the renal disease of most examples of murine lupus. Cyclophosphamide markedly reduces the elevated myb RNA in MRL-lpr/lpr mice lymph nodes and increases the very low thymic myb expression. Cyclosporin A, a drug which interferes with T cell function, is effective treatment for the arthritis, nephritis, and lymphoproliferation of MRL-lpr/lpr mice.