Control of gastrointestinal tumour progression by therapeutic interference with myeloid derived cells

通过治疗干扰骨髓来源细胞来控制胃肠道肿瘤进展

• 批准号: nhmrc : 1067244
• 负责人: A/Pr Martin Lackmann
• 金额: $ 50.59万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-gastrointestinal-tumour-derived-cells/455295
• 关键词: Control; gastrointestinal; tumour; progression; therapeutic

Cancers of the stomach and the colon are a major health burden. Despite our increased molecular understanding of the mutation that cause these cancers our treatment options are very limited. Here we will use sophisticated and validated mouse models for these cancers to establish how blood-borne cells contribute to the growth and spreading of these cancer. We will use these models to establish highly effective treatment combinations of therapeutic agents that are already undergoing preclinical testing.

胃癌和结肠癌是主要的健康负担。尽管我们对导致这些癌症的突变有了更多的分子理解，但我们的治疗选择非常有限。在这里，我们将使用先进和有效的小鼠模型来治疗这些癌症，以确定血液传播的细胞如何促进这些癌症的生长和扩散。我们将使用这些模型来建立已经在进行临床前测试的治疗剂的高效治疗组合。