Stage II in the development of Eph/ephrin based tumor targeting reagents: Optimisation of drug efficacy and delivery
Stage II in the development of Eph/ephrin based tumor targeting reagents: Optimisation of drug efficacy and delivery
批准号:
nhmrc : 284418
负责人:
A/Pr Martin Lackmann
金额:
$13.61万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Development Grants
财政年份:
2004
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2004-01-01 至 2005-12-31
中文摘要
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英文摘要
In the final stage of cancer, including melanoma, tumor cells gain the ability to spread, a process called metastasis. Altered communication between cancer and normal cells is one of the causes of this invasive characteristic. We have started the development of novel agents that target and modulate proteins on the cell surface that control these properties and are found in metastatic tumors. We propose to refine the targeting and killing properties of these agents for early clinical testing.
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Antibody-based inhibition of ADAM10 as cancer immunotherapy
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批准号:nhmrc : 1067609
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项目类别:Project Grants
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资助金额:$43.53万
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财政年份:2014
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负责人:A/Pr Martin Lackmann
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依托单位:
Control of gastrointestinal tumour progression by therapeutic interference with myeloid derived cells
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依托单位:
Can inhibition of myeloid cell function suppress gastro-intestinal cancer?
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批准号:nhmrc : GNT1067244
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资助金额:$72.75万
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财政年份:2014
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负责人:A/Pr Martin Lackmann
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依托单位:
Inhibiting tumour growth by targeting EphA3 and disrupting tumour stromal and vascular microenvironment
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批准号:nhmrc : 1049942
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项目类别:Project Grants
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资助金额:$43.02万
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财政年份:2013
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负责人:A/Pr Martin Lackmann
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依托单位:
Receptor tyrosine kinase function as molecular target in cancer.
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批准号:nhmrc : 1003908
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项目类别:NHMRC Research Fellowships
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资助金额:$27.72万
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财政年份:2011
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负责人:A/Pr Martin Lackmann
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依托单位:
The role of protein tyrosine phosphatases regulating Eph RTK-signalling and modulating invasive tumour cell properties.
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批准号:nhmrc : 436774
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项目类别:NHMRC Project Grants
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资助金额:$20.26万
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财政年份:2007
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负责人:A/Pr Martin Lackmann
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依托单位:
EphA3-modulated cell positioning in tumour invasion and neovascularisation.
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批准号:nhmrc : 384241
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项目类别:NHMRC Project Grants
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资助金额:$43.16万
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财政年份:2006
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负责人:A/Pr Martin Lackmann
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依托单位:
Research Fellowship - Grant ID:384113
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批准号:nhmrc : 384113
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项目类别:NHMRC Research Fellowships
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资助金额:$36.6万
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财政年份:2006
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负责人:A/Pr Martin Lackmann
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依托单位:
Functional analysis of the molecular switch that regulates ADAM10-mediated cleavage of RTK ligands in tumour cells.
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批准号:nhmrc : 384242
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项目类别:NHMRC Project Grants
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资助金额:$30.49万
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财政年份:2006
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负责人:A/Pr Martin Lackmann
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依托单位:
The Role of Eph/ephrin clustering and trafficking in control of tumour cell invasion
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批准号:nhmrc : 334085
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项目类别:NHMRC Project Grants
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资助金额:$29.31万
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财政年份:2005
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负责人:A/Pr Martin Lackmann
-
依托单位:
Development of anti-metastatic and tumour targeting reagents by design of inhibitors to specific Eph/ephrin cell-cell
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批准号:nhmrc : 234712
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项目类别:NHMRC Development Grants
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资助金额:$13.34万
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财政年份:2003
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负责人:A/Pr Martin Lackmann
-
依托单位:
Development and evaluation of biological reagents targeting and inhibiting function of the EphA3 receptor on tumor cells
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批准号:nhmrc : 234707
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项目类别:NHMRC Project Grants
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资助金额:$32.71万
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财政年份:2003
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负责人:A/Pr Martin Lackmann
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依托单位:
Signal transduction pathways of EphA receptor tyrosine kinases
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批准号:nhmrc : 991280
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项目类别:NHMRC Project Grants
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资助金额:$12.15万
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财政年份:1999
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负责人:A/Pr Martin Lackmann
-
依托单位:
国内基金
海外基金
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