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Antibody-based inhibition of ADAM10 as cancer immunotherapy

Antibody-based inhibition of ADAM10 as cancer immunotherapy
基于抗体的 ADAM10 抑制作为癌症免疫疗法
批准号:
nhmrc : 1067609
负责人:
A/Pr Martin Lackmann
金额:
$43.53万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31

项目摘要

项目成果

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中文摘要
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英文摘要
Despite our advances in understanding the molecular basis of cancer, treatments for metastatic cancers are limited, emphasising an urgent need for strategies targeting several oncogenic pathways. We generated monoclonal antibodies effectively blocking the activity of ADAM10, an oncogenic cell surface protease that activates tumour growth, invasion and metastasis through multiple pathways. Here we describe the strategies that progress these antibodies as lead therapeutics for clinical testing.
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