Can inhibition of myeloid cell function suppress gastro-intestinal cancer?

抑制骨髓细胞功能可以抑制胃肠癌吗？

• 批准号: nhmrc : GNT1067244
• 负责人: A/Pr Martin Lackmann
• 金额: $ 72.75万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inhibition-myeloid-cell-intestinal-cancer/1344932
• 关键词: inhibition; myeloid; cell; function; suppress

Cancers of the stomach and the colon are a major health burden. Despite our increased molecular understanding of the mutation that cause these cancers our treatment options are very limited. Here we will use sophisticated and validated mouse models for these cancers to establish how blood-borne cells contribute to the growth and spreading of these cancer. We will use these models to establish highly effective treatment combinations of therapeutic agents that are already undergoing preclinical testing.

胃癌和结肠癌是主要的健康负担。尽管我们对导致这些癌症的突变的分子了解不断增加，但我们的治疗选择仍然非常有限。在这里，我们将使用针对这些癌症的复杂且经过验证的小鼠模型来确定血源性细胞如何促进这些癌症的生长和扩散。我们将利用这些模型建立高效的治疗药物组合，这些治疗药物已经在进行临床前测试。