Can inhibition of myeloid cell function suppress gastro-intestinal cancer?
Can inhibition of myeloid cell function suppress gastro-intestinal cancer?
批准号:
nhmrc : GNT1067244
负责人:
A/Pr Martin Lackmann
金额:
$72.75万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 --
中文摘要
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英文摘要
Cancers of the stomach and the colon are a major health burden. Despite our increased molecular understanding of the mutation that cause these cancers our treatment options are very limited. Here we will use sophisticated and validated mouse models for these cancers to establish how blood-borne cells contribute to the growth and spreading of these cancer. We will use these models to establish highly effective treatment combinations of therapeutic agents that are already undergoing preclinical testing.
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会议论文
Antibody-based inhibition of ADAM10 as cancer immunotherapy
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批准号:nhmrc : 1067609
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项目类别:Project Grants
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资助金额:$43.53万
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财政年份:2014
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负责人:A/Pr Martin Lackmann
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依托单位:
Control of gastrointestinal tumour progression by therapeutic interference with myeloid derived cells
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批准号:nhmrc : 1067244
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项目类别:Project Grants
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资助金额:$50.59万
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财政年份:2014
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负责人:A/Pr Martin Lackmann
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依托单位:
Inhibiting tumour growth by targeting EphA3 and disrupting tumour stromal and vascular microenvironment
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批准号:nhmrc : 1049942
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项目类别:Project Grants
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资助金额:$43.02万
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财政年份:2013
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负责人:A/Pr Martin Lackmann
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依托单位:
Receptor tyrosine kinase function as molecular target in cancer.
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批准号:nhmrc : 1003908
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项目类别:NHMRC Research Fellowships
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资助金额:$27.72万
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财政年份:2011
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负责人:A/Pr Martin Lackmann
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依托单位:
The role of protein tyrosine phosphatases regulating Eph RTK-signalling and modulating invasive tumour cell properties.
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批准号:nhmrc : 436774
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项目类别:NHMRC Project Grants
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资助金额:$20.26万
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财政年份:2007
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负责人:A/Pr Martin Lackmann
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依托单位:
EphA3-modulated cell positioning in tumour invasion and neovascularisation.
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批准号:nhmrc : 384241
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项目类别:NHMRC Project Grants
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资助金额:$43.16万
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财政年份:2006
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负责人:A/Pr Martin Lackmann
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依托单位:
Research Fellowship - Grant ID:384113
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批准号:nhmrc : 384113
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项目类别:NHMRC Research Fellowships
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资助金额:$36.6万
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财政年份:2006
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负责人:A/Pr Martin Lackmann
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依托单位:
Functional analysis of the molecular switch that regulates ADAM10-mediated cleavage of RTK ligands in tumour cells.
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批准号:nhmrc : 384242
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项目类别:NHMRC Project Grants
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资助金额:$30.49万
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财政年份:2006
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负责人:A/Pr Martin Lackmann
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依托单位:
The Role of Eph/ephrin clustering and trafficking in control of tumour cell invasion
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批准号:nhmrc : 334085
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项目类别:NHMRC Project Grants
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资助金额:$29.31万
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财政年份:2005
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负责人:A/Pr Martin Lackmann
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依托单位:
Stage II in the development of Eph/ephrin based tumor targeting reagents: Optimisation of drug efficacy and delivery
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批准号:nhmrc : 284418
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项目类别:NHMRC Development Grants
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资助金额:$13.61万
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财政年份:2004
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负责人:A/Pr Martin Lackmann
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依托单位:
Development of anti-metastatic and tumour targeting reagents by design of inhibitors to specific Eph/ephrin cell-cell
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批准号:nhmrc : 234712
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项目类别:NHMRC Development Grants
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资助金额:$13.34万
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财政年份:2003
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负责人:A/Pr Martin Lackmann
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依托单位:
Development and evaluation of biological reagents targeting and inhibiting function of the EphA3 receptor on tumor cells
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批准号:nhmrc : 234707
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项目类别:NHMRC Project Grants
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资助金额:$32.71万
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财政年份:2003
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负责人:A/Pr Martin Lackmann
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依托单位:
Signal transduction pathways of EphA receptor tyrosine kinases
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批准号:nhmrc : 991280
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项目类别:NHMRC Project Grants
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资助金额:$12.15万
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财政年份:1999
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负责人:A/Pr Martin Lackmann
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依托单位:
国内基金
海外基金
S100A8/A9--Myeloid cells特异性可溶性表氧化物水解酶(sEH)基因敲除改善胰岛素抵抗的新靶点
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批准号:82070825
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项目类别:面上项目
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资助金额:53.0万元
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批准年份:2020
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负责人:徐西振
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依托单位:
STAT3/IDO途径参与乳腺癌髓系来源抑制细胞(MDSCs)下调T细胞免疫及相关机制探讨
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批准号:81072159
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项目类别:面上项目
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资助金额:32.0万元
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批准年份:2010
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负责人:于津浦
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依托单位: