Control of Salvador-Warts-Hippo Pathway activity in Drosophila and mammals

果蝇和哺乳动物萨尔瓦多-疣-河马途径活性的控制

• 批准号: nhmrc : 566700
• 负责人: Prof Kieran Harvey
• 金额: $ 34.28万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-salvador-warts-drosophila-mammals/99422
• 关键词: Control; Salvador; Warts; Hippo; Pathway

The primary function of the Salvador-Warts-Hippo (SWH) pathway is to dictate the appropriate size of organs in developing animals. Deregulation of this pathway results in vastly overgrown organs and can lead to the formation of cancer in humans. Our study will provide important insights into how the size of organs are controlled during development by identifying new SWH pathway components. We will also increase understanding of diseases that arise due to aberrant tissue growth, such as cancer.

萨尔瓦多-沃茨-河马(SWH)途径的主要功能是决定发育中动物器官的适当大小。放松对这一途径的管制会导致器官过度生长，并可能导致人类癌症的形成。我们的研究将通过识别新的SWH途径组件，为如何在发育过程中控制器官大小提供重要的见解。我们还将增加对组织异常生长引起的疾病的了解，如癌症。