Investigating Hippo-regulated transcription at single molecule resolution

以单分子分辨率研究河马调控的转录

• 批准号: DP220102523
• 负责人: Prof Kieran Harvey
• 金额: $ 36.25万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102523
• 关键词: Investigating; Hippo; regulated; transcription; single

Signalling pathways operate throughout life to relay signals from the extracellular world to the cellular nucleus, to control transcription and elicit a response. This project aims to understand how the Hippo growth control pathway regulates transcription. Using a combination of biology, biophysics and computational biology, this project aims to quantify behaviour of the Hippo pathway transcription factors at sub-micron resolution, and how Hippo signalling modulates their behaviour, interaction with the genome and function. We anticipate our discoveries will stimulate new research, e.g. testing of how other signaling pathways regulate transcription. Intended benefits are creation of jobs and new knowledge on fundamental principles of life.

信号通路在整个生命过程中发挥作用，将信号从细胞外世界传递到细胞核，以控制转录并引发反应。该项目旨在了解Hippo生长控制途径如何调节转录。利用生物学，生物物理学和计算生物学的组合，该项目旨在以亚微米分辨率量化Hippo途径转录因子的行为，以及Hippo信号传导如何调节它们的行为，与基因组和功能的相互作用。我们预计我们的发现将刺激新的研究，例如测试其他信号通路如何调节转录。预期的好处是创造就业机会和关于生活基本原则的新知识。