How neurons maintain their fate

神经元如何维持其命运

• 批准号: DP190101743
• 负责人: Prof Kieran Harvey
• 金额: $ 31.94万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-17 至 2022-06-16
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190101743
• 关键词: How; neurons; maintain; their; fate

This project aims to investigate how neurons maintain their identity, without reverting back to less specialised cells. Stable fate maintenance is essential because when it fails, cells lose their ability to perform their ascribed function, which impedes organism fitness. This project aims to define how two proteins work in partnership to maintain the identity of brain neurons. We intend our discoveries to stimulate new research, for example to test whether the human counterparts of the Drosophila proteins studied here, function similarly. Benefits will be provided in the form of job creation, and new knowledge in fundamental aspects of life, including brain development and cell fate maintenance.

该项目旨在研究神经元如何保持其身份，而不会恢复到不太专业的细胞。维持稳定的命运是至关重要的，因为当它失败时，细胞失去了执行其既定功能的能力，这阻碍了生物体的健康。该项目旨在确定两种蛋白质如何合作以维持大脑神经元的身份。我们希望我们的发现能够刺激新的研究，例如测试这里研究的果蝇蛋白质的人类对应物是否具有类似的功能。福利将以创造就业机会的形式提供，并提供生活基本方面的新知识，包括大脑发育和细胞命运维持。