The Hippo signalling pathway in dividing and non-dividing cells

分裂细胞和非分裂细胞中的 Hippo 信号通路

• 批准号: DP180102044
• 负责人: Prof Kieran Harvey
• 金额: $ 31.23万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-05-30 至 2021-08-27
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180102044
• 关键词: Hippo; signalling; pathway; dividing; non

This project aims to understand how the Drosophila Hippo pathway performs two very different jobs in the same organ, that is control cell proliferation and differentiation. The redeployment of cellular machinery to do different jobs is very common and efficient, but the mechanism by which this occurs is poorly understood. Using new techniques, this project aims to provide new knowledge to several fields including organ growth control, cell fate specification, cellular signalling and eye vision. These discoveries are likely to enhance international collaborations and stimulate new research.

该项目旨在了解果蝇海马通路如何在同一器官中执行两个非常不同的工作，即控制细胞增殖和分化。重新部署细胞机器来完成不同的工作是非常常见和有效的，但这种情况发生的机制却知之甚少。利用新技术，该项目旨在为包括器官生长控制、细胞命运规范、细胞信号传导和眼睛视觉在内的几个领域提供新知识。这些发现可能会加强国际合作并刺激新的研究。