Control of organ size during development and disease by the Salvadore-Warts-Hippo pathway

通过 Salvadore-Warts-Hippo 途径控制发育和疾病过程中的器官大小

• 批准号: nhmrc : 509347
• 负责人: Prof Kieran Harvey
• 金额: $ 22.12万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-organ-size-hippo-pathway/115537
• 关键词: Control; organ; size; during; development

Cancer is a disease that results from the generation of too many cells. Many signalling pathways control cell number including the newly identified Salvador-Warts-Hippo pathway. We are studying the mechanisms by which activity of this pathway is controlled, using the vinegar fly as a model. Information obtained from our study will aid understanding of human cancer as cellular processes which go awry in cancer, such as cell proliferation and death, are highly conserved between flies and humans.

癌症是一种由过多细胞产生的疾病。许多信号通路控制细胞数量，包括新发现的Salvador-Warts-Hippo通路。我们正在研究控制这一途径活动的机制，以醋蝇为模型。从我们的研究中获得的信息将有助于理解人类癌症，因为在癌症中出错的细胞过程，如细胞增殖和死亡，在苍蝇和人类之间高度保守。