Control of organ size during development and disease by the Salvadore-Warts-Hippo pathway
Control of organ size during development and disease by the Salvadore-Warts-Hippo pathway
批准号:
nhmrc : 509347
负责人:
Prof Kieran Harvey
金额:
$22.12万
依托单位国家:
澳大利亚
项目类别:
Career Development Fellowships
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
癌症是一种由于产生过多细胞而引起的疾病。许多信号通路控制细胞数量,包括新发现的萨尔瓦多-疣-河马通路。我们正在研究控制这一途径活动的机制,以醋蝇为模型。从我们的研究中获得的信息将有助于理解人类癌症,因为在癌症中出错的细胞过程,如细胞增殖和死亡,在苍蝇和人类之间高度保守。
英文摘要
Cancer is a disease that results from the generation of too many cells. Many signalling pathways control cell number including the newly identified Salvador-Warts-Hippo pathway. We are studying the mechanisms by which activity of this pathway is controlled, using the vinegar fly as a model. Information obtained from our study will aid understanding of human cancer as cellular processes which go awry in cancer, such as cell proliferation and death, are highly conserved between flies and humans.
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批准号:DP230101406
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项目类别:Discovery Projects
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资助金额:$27.24万
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财政年份:2023
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负责人:Prof Kieran Harvey
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依托单位:
Investigating Hippo-regulated transcription at single molecule resolution
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批准号:DP220102523
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负责人:Prof Kieran Harvey
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How neurons maintain their fate
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批准号:DP190101743
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项目类别:Discovery Projects
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资助金额:$31.94万
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财政年份:2019
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负责人:Prof Kieran Harvey
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依托单位:
The Hippo pathway and melanoma growth
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批准号:nhmrc : 1145166
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项目类别:Project Grants
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资助金额:$54.73万
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财政年份:2018
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负责人:Prof Kieran Harvey
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依托单位:
The Hippo pathway and melanoma growth
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批准号:nhmrc : GNT1145166
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项目类别:Project Grants
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资助金额:$80.95万
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财政年份:2018
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负责人:Prof Kieran Harvey
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依托单位:
The Hippo signalling pathway in dividing and non-dividing cells
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批准号:DP180102044
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项目类别:Discovery Projects
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资助金额:$31.23万
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财政年份:2018
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负责人:Prof Kieran Harvey
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依托单位:
Control of organ size and cancer by the Hippo pathway
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批准号:nhmrc : GNT1078220
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项目类别:Research Fellowships
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资助金额:$61.16万
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财政年份:2015
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负责人:Prof Kieran Harvey
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依托单位:
Control of transcription by the Hippo pathway
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批准号:nhmrc : GNT1080131
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项目类别:Project Grants
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资助金额:$40.9万
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财政年份:2015
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负责人:Prof Kieran Harvey
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依托单位:
Control of transcription by the Hippo pathway
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批准号:nhmrc : 1080131
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项目类别:Project Grants
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资助金额:$42.19万
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财政年份:2015
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负责人:Prof Kieran Harvey
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依托单位:
Control of organ size and cancer by the Hippo pathway
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批准号:nhmrc : 1078220
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项目类别:Research Fellowships
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资助金额:$42.58万
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财政年份:2015
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负责人:Prof Kieran Harvey
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依托单位:
Characterisation of two new kinases in the Hippo tumour suppressor pathway
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批准号:nhmrc : 1060090
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项目类别:Project Grants
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资助金额:$36.71万
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财政年份:2014
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负责人:Prof Kieran Harvey
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依托单位:
Wbp2, a new regulator of the Hippo tumor suppressor pathway
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批准号:nhmrc : 1020318
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项目类别:Project Grants
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资助金额:$39.07万
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财政年份:2012
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负责人:Prof Kieran Harvey
-
依托单位:
GTPase regulation of the Hippo organ size-control pathway
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批准号:nhmrc : 1020316
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项目类别:Project Grants
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资助金额:$38.03万
-
财政年份:2012
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负责人:Prof Kieran Harvey
-
依托单位:
Tao kinase, a new member of the Hippo tumour suppressor pathway
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批准号:nhmrc : 1032551
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项目类别:Project Grants
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资助金额:$40.35万
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财政年份:2012
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负责人:Prof Kieran Harvey
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依托单位:
Control of Salvador-Warts-Hippo Pathway activity in Drosophila and mammals
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批准号:nhmrc : 566700
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项目类别:NHMRC Project Grants
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资助金额:$34.28万
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财政年份:2009
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负责人:Prof Kieran Harvey
-
依托单位:
How does Fat cadherin control organ size in Drosophila, and cancer in humans?
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批准号:DP0985049
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项目类别:Discovery Projects
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资助金额:$20.08万
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财政年份:2009
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负责人:Prof Kieran Harvey
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依托单位:
Examination of the mechanism by which the salvador/warts/hippo complex restricts cell growth and number
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批准号:nhmrc : 400335
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项目类别:NHMRC Project Grants
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资助金额:$18.92万
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财政年份:2006
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负责人:Prof Kieran Harvey
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依托单位:
国内基金
海外基金
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