How does Fat cadherin control organ size in Drosophila, and cancer in humans?

脂肪钙粘蛋白的主要功能是决定发育中动物器官的适当大小。脂肪基因的缺乏会导致器官过度生长，并可能导致人类癌症的形成。我们的研究将为了解器官的大小在发育过程中是如何控制的提供重要的见解。我们的研究结果将对人类健康和生物学的几个方面产生重要影响，并将增加我们对由于异常组织生长而引起的疾病（如癌症）的理解。我们的研究结果将因此对国家产生重大利益，因为癌症现在是澳大利亚最大的死亡原因，每年有88，000多名澳大利亚人被诊断患有癌症。

The primary function of Fat cadherin is to dictate the appropriate size of organs in developing animals. Deficiency in the fat gene results in vastly overgrown organs and can lead to the formation of cancer in humans. Our study will provide important insights into how the size of organs are controlled during development. Our research findings will have important implications for several aspects of human health and biology, and will increase our understanding of diseases that arise due to aberrant tissue growth, such as cancer. Our research findings will thus be of substantial national benefit, given that cancer is now the biggest cause of death in Australia, and that more than 88,000 Australians are diagnosed with cancer each year.