How does Fat cadherin control organ size in Drosophila, and cancer in humans?

脂肪钙粘蛋白如何控制果蝇的器官大小和人类的癌症？

• 批准号: DP0985049
• 负责人: Prof Kieran Harvey
• 金额: $ 20.08万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0985049
• 关键词: How; does; Fat; cadherin; control

The primary function of Fat cadherin is to dictate the appropriate size of organs in developing animals. Deficiency in the fat gene results in vastly overgrown organs and can lead to the formation of cancer in humans. Our study will provide important insights into how the size of organs are controlled during development. Our research findings will have important implications for several aspects of human health and biology, and will increase our understanding of diseases that arise due to aberrant tissue growth, such as cancer. Our research findings will thus be of substantial national benefit, given that cancer is now the biggest cause of death in Australia, and that more than 88,000 Australians are diagnosed with cancer each year.

脂肪钙蛋白的主要功能是决定发育中的动物中适当的器官大小。脂肪基因的缺乏会导致大量生长的器官，并可能导致人类的癌症形成。我们的研究将提供有关在开发过程中如何控制器官大小的重要见解。我们的研究发现将对人类健康和生物学的几个方面具有重要意义，并将增加我们对由于组织生长（例如癌症）引起的疾病的理解。因此，鉴于癌症现在是澳大利亚最大的死亡原因，我们的研究结果将具有很大的国家利益，并且每年被诊断出88,000名澳大利亚人。