The Hippo pathway and melanoma growth

Hippo途径和黑色素瘤生长

• 批准号: nhmrc : 1145166
• 负责人: Prof Kieran Harvey
• 金额: $ 54.73万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/hippo-pathway-melanoma-growth/1320373
• 关键词: Hippo; pathway; melanoma; growth

An exciting area of drug discovery involves targeting Hippo pathway proteins, particularly one called YAP, which were discovered by members of our research team and which are highly active in some cancer cells, making them grow and spread. We will test whether YAP is a potential drug target to prevent or treat melanoma, a deadly type of cancer that usually arises in the skin but also internal organs and the eye. If so, we would fast-track these drugs for testing in patients via clinical trials.

药物发现的一个令人兴奋的领域涉及靶向河马途径蛋白，特别是一种名为YAP的蛋白，这种蛋白是我们的研究团队成员发现的，它在一些癌细胞中非常活跃，使它们生长和扩散。我们将测试YAP是否为预防或治疗黑色素瘤的潜在药物靶点。黑色素瘤是一种致命的癌症，通常发生在皮肤上，但也会发生在内脏和眼睛上。如果是这样的话，我们将快速追踪这些药物，以便通过临床试验在患者身上进行测试。