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MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION

MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
淋巴细胞功能的分子遗传学分析
批准号：
3746531
负责人：
D H MARGULIES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3746531
关键词：
MHC class I antigen T cell receptor antigen presentation immunogenetics leukocyte activation /transformation mathematical model natural killer cells receptor binding surface antigens

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英文摘要
The focus of these studies has been on the functional role of the MHC class I molecule and the development of model systems for examining this function both in vitro and in vivo. Specific accomplishments during the past year include: 1) quantitative measurement of the interaction of MHC class I molecules-peptide complexes with T cell receptors; 2) the evaluation of the role of the MHC class I molecule H-2Dd in the signalling of a subset of NK cells bearing the cell surface marker Ly-49; 3) the quantitative evaluation and mathematical modeling of the contribution of MHC and peptide to T cell stimulation; and 4) the production of single chain MHC class I molecules for functional and binding studies.
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MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
IN VITRO MEASUREMENT OF BINDING OF SELF AND ANTIGENIC PEPTIDES TO MHC MOLECULES
MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
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