CARBOHYDRATE RECEPTORS FOR HUMAN PATHOGENS

人类病原体的碳水化合物受体

• 批准号: 3752081
• 负责人: D D ROBERTS
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3752081
• 关键词: Candida albicans; bacterial cytopathogenic effect; binding proteins; carbohydrate receptor; cell adhesion; collagen; fibronectins; gelatin; glycoprotein structure; glycoproteins; heparin; human tissue; molecular site; protein purification; receptor binding; receptor expression

Adhesive specificities of Staphylococcus aureus, some Enterococcus species, Candida albicans, and elementary bodies of Chlamydia trachomatis are being examined. These have been screened for binding to extracellular matrix proteins and glycoproteins and glycolipids of known structure and to glycoconjugates isolated from target tissues to which the pathogens adhere. Where possible, inhibitors of each binding specificity will be identified using the solid phase assays and then tested using in vitro cytoadherence as says and in vivo infection assays to determine the role of each in cytoadherence and initiation of infection.

金黄色葡萄球菌、某些肠球菌的粘附特异性 种、白色念珠菌和沙眼衣原体原体 正在接受检查。 这些已被筛选为结合细胞外 已知结构的基质蛋白和糖蛋白和糖脂， 涉及从病原体所针对的靶组织分离的糖缀合物， 坚持。 在可能的情况下，每种结合特异性的抑制剂将是 使用固相测定法鉴定，然后使用体外 细胞粘附和体内感染试验来确定 在细胞粘附和感染启动中的作用。