GLYCOLIPID ANTIGENS EXPRESSED IN CANCER CELLS

糖脂和糖蛋白的改变的糖基化通常是 在肿瘤组织和培养的癌细胞系中观察到。 变化 糖基转移酶的表达产生独特的糖结构 其可用于区分肿瘤与正常组织， 病例改变了粘附蛋白和受体的生物活性 其携带改变的寡糖。 我们正在研究 某些识别寡糖单克隆抗体特异性 功能重要分子和结构的决定因素 由癌细胞产生的硫酸化糖缀合物结合到粘附剂上 蛋白质如层粘连蛋白和血小板反应蛋白。 目前，我们正在研究 人乳腺癌中产生的globo系列硫酸化糖脂， 由抗人分泌型白细胞介素1单克隆抗体识别的碳水化合物 一种识别糖蛋白和糖脂的成分， 结肠腺癌

Altered glycosylation of glycolipids and glycoproteins is frequently observed in tumor tissues and cultured cancer cell lines. Changes in expression of glycosyltransferases produce unique carbohydrate structures which can be used to differentiate tumor from normal tissue and in some cases alter the biological activity of adhesive proteins and receptors which bear the altered oligosaccharides. We are examining the specificity of some monoclonal antibodies that recognize oligosaccharide determinatants on functionally important molecules and the structures of sulfated glycoconjugates produced by cancer cells which bind to adhesive proteins such as laminin and thrombospondin. Currently we are examining globo-series sulfated glycolipids produced in human breast cancer and carbohydrates recognized by a monoclonal antibody to human secretory component which recognizes glycoproteins and glycolipids produced in colon adenocarcinomas.