CARBOHYDRATE RECEPTORS FOR HUMAN PATHOGENS

人类病原体的碳水化合物受体

• 批准号: 3813428
• 负责人: D D ROBERTS
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3813428
• 关键词: Candida albicans; Chlamydia trachomatis; Mycoplasma pneumoniae; adhesin; antireceptor antibody; bacterial antigens; binding proteins; carbohydrate receptor; carbohydrate sequence; carbohydrate structure; cell adhesion; chlamydial disease; fibronectins; glycolipids; glycoproteins; heparin; human tissue; laminin; monoclonal antibody; mycoplasmal pneumonia; receptor binding; sialate; sulfates; tissue /cell culture

Adhesive specificities of some Enterococcus species, Candida albicans, and elementary bodies of Chlamydia trachomatis are being examined. These will be screened for binding to glycoproteins and glycolipids of known structure and to glycoconjugates isolated from target tissues to which the pathogens adhere. Where possible, inhibitors of each binding specificity will be identified using the solid phase assays and then tested using in vitro cytoadherence assays and in vivo infection assays to determine the role of each in cytoadherence and initiation of infection.

某些肠球菌属、白色念珠菌和 正在检查沙眼衣原体的基本体。这些将 筛选与已知结构的糖蛋白和糖脂的结合 以及从病原体所针对的靶组织分离的糖缀合物 坚持。在可能的情况下，每种结合特异性的抑制剂将是 使用固相测定法鉴定，然后使用体外 细胞粘附试验和体内感染试验，以确定 每一种都在细胞粘附和感染的开始中。