Copper and its antibacterial action: an emerging aspect of host defence against bacterial pathogens

铜及其抗菌作用：宿主防御细菌病原体的一个新兴方面

• 批准号: nhmrc : 519722
• 负责人: Prof Alastair Mcewan
• 金额: $ 30.33万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/copper-antibacterial-action-bacterial-pathogens/81245
• 关键词: Copper; its; antibacterial; action; emerging

This project will determine the way in which copper is used as an antimicrobial agent to kill Salmonella that reside inside the macrophage (white blood cell) of the host and also determine how Salmonella defends against copper-dependent killing. It will also determine the role of copper in the killing of extra-intestinal pathogens during sepsis. These results will provide information that can be used to manage and control infections intracellular and extracellular bacterial pathogens.

该项目将确定铜作为抗菌剂杀死宿主巨噬细胞（白细胞）内沙门氏菌的方式，并确定沙门氏菌如何防御铜依赖性杀伤。它还将确定铜在脓毒症期间杀死肠外病原体中的作用。这些结果将提供可用于管理和控制细胞内和细胞外细菌病原体感染的信息。