EFFECT ON AMPHETAMINE ON CEREBRAL BLOOD FLOW IN SCHIZOPHRENIA

在过去的一年里，我们试图描述认知的各个方面， 精神分裂症的失败 特别是，我们有： 1.使用各种所谓的测试来检查工作记忆功能 中央执行系统、视觉系统、语言系统和奴隶系统 响应范式。 2.检查语义记忆，以确定是否混乱 可能会影响精神分裂症患者 communicate. 我们试图描述语义上的差异 我们使用各种不同的语言， 启动技术，以确定是否存在过度激活语义 与“思维障碍”共变的关联网络。" 3.试图测试幻觉行为的妄想理论， 精神分裂症，前提是一个“中心”， 第二个“中心”负责监控行动。 我们已经使用 延迟听觉反馈来评估这个理论。 4.通过对认知型精神分裂症患者的研究， 评估患者在神经心理测试中的表现， 接受氯氮平、氟哌啶醇或安慰剂。 5.通过评估认知功能， 双胞胎双相情感障碍患者，额叶癫痫患者， 以及脑外伤患者的情况。 6.自传体测验评估精神分裂症患者的远程记忆 知识、名人信息和语义信息。 7.测量安非他明对正常人认知功能的影响， 与不同认知任务交互作用时对大脑皮层的影响 通过PET 015的血流。

For the past year we attempted to characterize various facets of cognitive failure in schizophrenia. In particular we have: 1. Examined working memory function using a variety of tests of so called central executive and visual and verbal and slave systems through delayed response paradigms. 2. Examining semantic memory in order to ascertain if disorganization might have effects on the ability of schizophrenic patients to communicate. We are trying to characterize differences between semantic verbal and fluency and phonological verbal fluency we are using various priming techniques to determine if there is overactivation semantic associative networks in schizophrenia that covary with "thought disorder." 3. Attempted to test the theory of delusion on hallucinatory behavior in schizophrenia that premises disconnection between a "center" that initiates action and a second "center" that monitors action. We have used delayed auditory feedback to assess this theory. 4. Examined the effects of neuroleptics on cognition schizophrenia by assessing patients' performance on neuropsychological test while they received clozapine, haloperidol or placebo. 5. Invested neuropsychological, specificity by assessing cognitive in twins discordant for bipolar illness, patients with frontal lobe epilepsy, and in patients with traumatic brain injury. 6. Assessed remote memory in schizophrenia in by testing auto biographical knowledge, information about famous people and semantic information. 7. Measured the effects of amphetamine on cognition in normal subjects and its effects while interacting with different cognitive tasks on cerebral blood flow by means of PET 015.