EFFECT ON AMPHETAMINE ON CEREBRAL BLOOD FLOW IN SCHIZOPHRENIA

安非他明对精神分裂症脑血流的影响

• 批准号: 3759440
• 负责人: T E GOLDBERG
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3759440
• 关键词: amphetamines; bipolar depression; brain injury; clozapine; cognition; delusions; epilepsy; frontal lobe /cortex; haloperidol; human subject; memory; neuropharmacologic agent; neuropharmacology; performance; schizophrenia

For the past year we attempted to characterize various facets of cognitive failure in schizophrenia. In particular we have: 1. Examined working memory function using a variety of tests of so called central executive and visual and verbal and slave systems through delayed response paradigms. 2. Examining semantic memory in order to ascertain if disorganization might have effects on the ability of schizophrenic patients to communicate. We are trying to characterize differences between semantic verbal and fluency and phonological verbal fluency we are using various priming techniques to determine if there is overactivation semantic associative networks in schizophrenia that covary with "thought disorder." 3. Attempted to test the theory of delusion on hallucinatory behavior in schizophrenia that premises disconnection between a "center" that initiates action and a second "center" that monitors action. We have used delayed auditory feedback to assess this theory. 4. Examined the effects of neuroleptics on cognition schizophrenia by assessing patients' performance on neuropsychological test while they received clozapine, haloperidol or placebo. 5. Invested neuropsychological, specificity by assessing cognitive in twins discordant for bipolar illness, patients with frontal lobe epilepsy, and in patients with traumatic brain injury. 6. Assessed remote memory in schizophrenia in by testing auto biographical knowledge, information about famous people and semantic information. 7. Measured the effects of amphetamine on cognition in normal subjects and its effects while interacting with different cognitive tasks on cerebral blood flow by means of PET 015.

在过去的一年里，我们试图描述认知的各个方面 精神分裂症的失败。 特别是我们有： 1. 使用各种所谓的测试来检查工作记忆功能 通过延迟的中枢执行、视觉、言语和从属系统 响应范式。 2. 检查语义记忆以确定是否混乱 可能会影响精神分裂症患者的能力 交流。 我们正在尝试描述语义之间的差异 我们正在使用各种语言和流利度以及语音语言流利度 启动技术来确定是否存在过度激活语义 精神分裂症中与“思维障碍”相关的联想网络。 3. 尝试检验妄想理论对幻觉行为的影响 精神分裂症以一个“中心”之间的脱节为前提 发起行动，第二个“中心”监控行动。 我们已经用过 延迟听觉反馈来评估这一理论。 4. 通过以下方法检查精神安定药对认知精神分裂症的影响 评估患者在神经心理学测试中的表现 接受氯氮平、氟哌啶醇或安慰剂。 5. 通过评估认知来研究神经心理学的特异性 患有双相情感障碍的双胞胎、额叶癫痫患者、 以及脑外伤患者。 6. 通过测试自传来评估精神分裂症的远程记忆 知识、名人信息和语义信息。 7. 测量安非他明对正常受试者认知的影响 与不同认知任务相互作用时对大脑的影响 PET 015 的血流。