NEUROPSYCHOLOGICAL TESTING

神经心理测试

• 批准号: 3781460
• 负责人: T E GOLDBERG
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3781460
• 关键词: amphetamines; antipsychotic agents; auditory feedback; brain injury; cognition; delusions; epilepsy; glucose; hallucinations; human subject; memory; mood disorders; neuropsychological tests; neuropsychology; partial seizure; psychopharmacology; schizophrenia; tardive dyskinesia; temporal lobe /cortex disorder

Over the past year, our work has been concentrated on better understand- ing various facets of schizophrenic cognition. In particular, we have examined: 1) Working memory. We have used a Brown Peterson paradigm with differ- ent cognitive loads to reexamine the capacity of this system in patients with schizophrenia. In addition, we have developed a number of novel tasks including a simple spatial delayed response, delayed alternation task and a letter-number span task. 2) Memory function. We have examined conditions under which schizo- phrenic patients may learn. These have included long list learning paradigms in which material is well encoded and also ecologically based paradigms with reward. 3) Atypical neuroleptics. We are comparing patients performance on neuropsychological tests while they are receiving clozapine or haloperi- dol. 4) Specificity. In order to better delineate the cognitive profile of schizophrenia, we are examining other groups of patients with neuropsy- chiatric diseases (affective disorder, temporal lobe epilepsy, and traumatic brain injury). 5) Cognitive enhancing strategies. We are comparing cognitive rehabili- tation techniques and glucose administration directly, continuing work with amphetamine as a cognitive enhancer, as well. 6) Cognitive accounts of symptomatology. Recent theoretical views of schizophrenia have suggested that delusions and hallucinations may be the result of a defective self monitoring system. We are assessing the validity of these theories using delayed auditory feedback. 7) We have developed a number of cognitive activation techniques to be used in PET studies and ligand studies in order to better understand the biological underpinnings of various types of mentation.

在过去一年中，我们的工作集中在更好地了解- 精神分裂症认知的各个方面。 我们特别 检查： 1)工作记忆 我们使用了布朗彼得森范式， 输入认知负荷以重新检查患者的这一系统的能力 精神分裂症 此外，我们还开发了一系列新颖的 任务包括简单的空间延迟反应，延迟交替 任务和字母数字跨度任务。 2)记忆功能。 我们已经研究了在何种条件下， 膈神经病患者可以学习。 其中包括长列表学习 材料被很好地编码并以生态为基础的范例 有奖励的典范 3)非典型的神经抑制剂。 我们正在比较患者的表现， 神经心理学测试，而他们正在接受氯氮平或氟哌啶， 多尔。 4)的特异性 为了更好地描述 精神分裂症，我们正在研究其他神经病患者群体- 儿童疾病（情感障碍、颞叶癫痫和 创伤性脑损伤）。 5)认知增强策略。 我们在比较认知能力- 葡萄糖直接给药，继续工作 安非他明作为认知增强剂。 6)认知学的解释。 最近的理论观点 精神分裂症表明，妄想和幻觉可能是 一个有缺陷的自我监控系统的结果。 我们正在评估 这些理论的有效性使用延迟听觉反馈。 7)我们已经开发了一些认知激活技术， 用于PET研究和配体研究，以便更好地了解 各种心理状态的生物学基础。