NEUROPSYCHOLOGICAL TESTING

一年来，我们的工作集中在更好地认识-- 精神分裂症认知的各个方面。特别是，我们有 已检查： 1)工作记忆。我们使用了布朗·彼得森范式，不同的是- ENT认知负荷对患者重新检查这一系统的能力 患有精神分裂症。此外，我们还开发了一些新颖的 任务包括简单的空间延迟反应、延迟交替 任务和字母-数字跨度任务。 2)记忆功能。我们研究了精神分裂的条件- 隔膜症患者可能会学到。其中包括长长的列表学习 材料编码良好且以生态为基础的范例 有奖赏的典范。 3)非典型抗精神病药物。我们正在比较患者的表现 在他们接受氯氮平或氟哌啶的同时进行神经心理测试- 多尔。 4)特异性。为了更好地描绘出人类的认知轮廓 精神分裂症，我们正在检查其他神经症患者- 儿科疾病(情感障碍、颞叶癫痫和 创伤性脑损伤)。 5)认知强化策略。我们正在比较认知康复- 试管技术和葡萄糖直接给药，继续工作 安非他命也是一种认知增强剂。 6)对症状学的认知描述。最新的理论观点 精神分裂症表明，妄想和幻觉可能是 自我监控系统有缺陷的结果。我们正在评估 使用延迟听觉反馈验证这些理论的正确性。 7)我们开发了一些认知激活技术，以成为 用于PET研究和配基研究，以便更好地了解 不同类型心理状态的生物学基础。

Over the past year, our work has been concentrated on better understand- ing various facets of schizophrenic cognition. In particular, we have examined: 1) Working memory. We have used a Brown Peterson paradigm with differ- ent cognitive loads to reexamine the capacity of this system in patients with schizophrenia. In addition, we have developed a number of novel tasks including a simple spatial delayed response, delayed alternation task and a letter-number span task. 2) Memory function. We have examined conditions under which schizo- phrenic patients may learn. These have included long list learning paradigms in which material is well encoded and also ecologically based paradigms with reward. 3) Atypical neuroleptics. We are comparing patients performance on neuropsychological tests while they are receiving clozapine or haloperi- dol. 4) Specificity. In order to better delineate the cognitive profile of schizophrenia, we are examining other groups of patients with neuropsy- chiatric diseases (affective disorder, temporal lobe epilepsy, and traumatic brain injury). 5) Cognitive enhancing strategies. We are comparing cognitive rehabili- tation techniques and glucose administration directly, continuing work with amphetamine as a cognitive enhancer, as well. 6) Cognitive accounts of symptomatology. Recent theoretical views of schizophrenia have suggested that delusions and hallucinations may be the result of a defective self monitoring system. We are assessing the validity of these theories using delayed auditory feedback. 7) We have developed a number of cognitive activation techniques to be used in PET studies and ligand studies in order to better understand the biological underpinnings of various types of mentation.