DEVELOPMENT OF COGNITIVE ACTIVATION TASKS FOR FUNCTIONAL NEUROIMAGING

功能神经影像认知激活任务的开发

• 批准号: 6162935
• 负责人: T E GOLDBERG
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162935
• 关键词: brain imaging /visualization /scanning; brain mapping; brain metabolism; cerebellum; clinical research; cognition; frontal lobe /cortex; functional magnetic resonance imaging; human subject; memory; neural information processing; neuropsychological tests; positron emission tomography; schizophrenia; verbal behavior

We have developed a variety of tasks to activate regions of interest in functional neuroimaging studies. 1. Using the n-back task we found a physiologic concomitant of capacity limitation in short-term memory. Key voxels in prefrontal cortex showed signal intensity plateaus or decreases with increasing load, not increases as might have been predicted. We are now examining the effects of pharmacological manipulation so in this system. First we are administering the indirect dopamine agonist amphetamine in normal controls in an attempt to increase capacity. Second we are using the NMDA antagonist ketamine to model capacity limitations in normal controls. 2. We developed a carefully matched set of verbal fluency tasks to examine the relation between semantic processing, thought disorder, and neurophysiology in schizophrenia using PET CBF methods. 3. To examine the levels of processing account of episodic memory we devised a series or recognition memory tasks. We also paid special attention to the development of a control task that would not involve active processing in the hope of better observing hippocampal activation.

我们已经开发了各种各样的任务来激活感兴趣的区域， 功能性神经影像学研究。 1.使用n-back任务，我们发现了一个生理伴随的能力 短期记忆的局限性。 前额叶皮层的关键体素显示 信号强度随着负载的增加而稳定或降低，而不是增加 正如我们所预料的那样。我们现在正在研究 在这个系统中进行药理学操作。首先，我们管理 尝试在正常对照组中使用间接多巴胺激动剂安非他明 以增加容量。 其次，我们使用NMDA拮抗剂氯胺酮， 正常对照中的模型容量限制。 2.我们精心设计了一套语言流畅性测试 语义处理、思维障碍和 使用PET CBF方法研究精神分裂症的神经生理学。 3.为了检验情景记忆的加工水平， 设计了一系列识别记忆任务。我们还特别支付了 注意控制任务的发展， 主动处理，希望更好地观察海马激活。